PDF(Pubmed)
Abstract：
UNASSIGNED: In this study, we investigated the value of molecular typing combined with integrated positron emission tomography (PET)/magnetic resonance imaging (MRI) semi-quantitative indices in endometrial cancer risk stratification.
UNASSIGNED: A retrospective study was conducted on 86 patients who were pathologically diagnosed with endometrial cancer and underwent surgical treatment after curettage at the Department of Obstetrics and Gynecology, Xuanwu Hospital, Capital Medical University between January 2017 and March 2023. Prior to surgery, each patient underwent integrated PET/MRI examination. The postoperative samples were subjected to pathological diagnosis, immunohistochemistry, and POLE gene sequencing. The differences in clinicopathological features between the four molecular subtypes and the differences in integrated PET/MRI semi-quantitative indexes (SUV max, ADC min) between the four molecular subtypes were analyzed. The cutoff value of molecular typing combined with integrated PET/MRI semi-quantitative indices for endometrial cancer risk stratification was determined.
UNASSIGNED: There were statistically significant differences in pathological types and tumor grades among the four molecular subtypes of endometrial cancer. The values of the four integrated PET/MRI semi-quantitative indices (SUV max and ADC min) of the molecular subtypes were statistically different. The SUV max was greater in the p53abn mutation group than in the POLE mutation group (P < 0.05). The ADC minimum of the POLE mutation group and the MMR-d group was lower than the NSMP group (P < 0.05). Molecular typing combined with the integrated PET/MRI semi-quantitative SUV max index can predict the low/medium risk group of endometrial cancer and the medium-high/high risk group, and the cut-off value of SUV max for predicting the risk of early endometrial cancer was 14.72 (sensitivity 66.7%, specificity 68.7%).
UNASSIGNED: Molecular typing combined with integrated PET/MRI semi-quantitative indicators is useful to achieve risk stratification in patients diagnosed with endometrial cancer and guide individualized treatment.
UNASSIGNED: A retrospective study was conducted on 86 patients who were pathologically diagnosed with endometrial cancer and underwent surgical treatment after curettage at the Department of Obstetrics and Gynecology, Xuanwu Hospital, Capital Medical University between January 2017 and March 2023. Prior to surgery, each patient underwent integrated PET/MRI examination. The postoperative samples were subjected to pathological diagnosis, immunohistochemistry, and POLE gene sequencing. The differences in clinicopathological features between the four molecular subtypes and the differences in integrated PET/MRI semi-quantitative indexes (SUV max, ADC min) between the four molecular subtypes were analyzed. The cutoff value of molecular typing combined with integrated PET/MRI semi-quantitative indices for endometrial cancer risk stratification was determined.
UNASSIGNED: There were statistically significant differences in pathological types and tumor grades among the four molecular subtypes of endometrial cancer. The values of the four integrated PET/MRI semi-quantitative indices (SUV max and ADC min) of the molecular subtypes were statistically different. The SUV max was greater in the p53abn mutation group than in the POLE mutation group (P < 0.05). The ADC minimum of the POLE mutation group and the MMR-d group was lower than the NSMP group (P < 0.05). Molecular typing combined with the integrated PET/MRI semi-quantitative SUV max index can predict the low/medium risk group of endometrial cancer and the medium-high/high risk group, and the cut-off value of SUV max for predicting the risk of early endometrial cancer was 14.72 (sensitivity 66.7%, specificity 68.7%).
UNASSIGNED: Molecular typing combined with integrated PET/MRI semi-quantitative indicators is useful to achieve risk stratification in patients diagnosed with endometrial cancer and guide individualized treatment.
摘要：
■在这项研究中，我们研究了分子分型联合正电子发射断层扫描(PET)/磁共振成像(MRI)半定量指标在子宫内膜癌危险分层中的价值.
对86例经病理诊断为子宫内膜癌并在妇产科刮宫后接受手术治疗的患者进行了回顾性研究，宣武医院,2017年1月至2023年3月的首都医科大学。手术前,每位患者均接受了完整的PET/MRI检查.术后标本均行病理诊断,免疫组织化学，和POLE基因测序。四种分子亚型之间临床病理特征的差异以及整合的PET/MRI半定量指标的差异（SUVmax，分析四种分子亚型之间的ADCmin)。确定分子分型结合整合PET/MRI半定量指标对子宫内膜癌风险分层的临界值。
■子宫内膜癌4种分子亚型在病理类型和肿瘤分级上存在统计学差异。分子亚型的4个整合PET/MRI半定量指标(SUVmax和ADCmin)的值具有统计学差异。p53abn突变组SUVmax大于POLE突变组(P<0.05)。POLE突变组和MMR-d组的ADC最小值低于NSMP组(P<0.05)。分子分型结合PET/MRI半定量SUVmax指数可预测子宫内膜癌的低/中风险组及中-高/高风险组。SUVmax预测早期子宫内膜癌风险的临界值为14.72（敏感性为66.7％，特异性68.7%)。
■分子分型结合整合的PET/MRI半定量指标有助于对诊断为子宫内膜癌的患者实现风险分层并指导个体化治疗。
对86例经病理诊断为子宫内膜癌并在妇产科刮宫后接受手术治疗的患者进行了回顾性研究，宣武医院,2017年1月至2023年3月的首都医科大学。手术前,每位患者均接受了完整的PET/MRI检查.术后标本均行病理诊断,免疫组织化学，和POLE基因测序。四种分子亚型之间临床病理特征的差异以及整合的PET/MRI半定量指标的差异（SUVmax，分析四种分子亚型之间的ADCmin)。确定分子分型结合整合PET/MRI半定量指标对子宫内膜癌风险分层的临界值。
■子宫内膜癌4种分子亚型在病理类型和肿瘤分级上存在统计学差异。分子亚型的4个整合PET/MRI半定量指标(SUVmax和ADCmin)的值具有统计学差异。p53abn突变组SUVmax大于POLE突变组(P<0.05)。POLE突变组和MMR-d组的ADC最小值低于NSMP组(P<0.05)。分子分型结合PET/MRI半定量SUVmax指数可预测子宫内膜癌的低/中风险组及中-高/高风险组。SUVmax预测早期子宫内膜癌风险的临界值为14.72（敏感性为66.7％，特异性68.7%)。
■分子分型结合整合的PET/MRI半定量指标有助于对诊断为子宫内膜癌的患者实现风险分层并指导个体化治疗。
