Abstract：
Alzheimer\'s disease (AD) is a neurological condition currently with 47 million people suffering from it globally. AD might have many reasons such as genetic issues, environmental factors, and Aβ accumulation, which is the biomarker of the disease. Since the primary reason is unknown, there is no targeted treatment at the moment, but ongoing research aims to slow its progression by managing amyloid-beta peptide production rather than symptomatic improvement. Since phytochemicals have been demonstrated to possess antioxidant, anti-inflammatory, and neuroprotective properties, they may target multiple pathological factors and can reduce the risk of the disease. Curcumin, as a phytochemical found in turmeric known for its antioxidant, free radical scavenging properties, and as an antiamyloid in treating AD, has come under investigation. Although its low bioavailability limits its efficacy, a prominent drug delivery system (DDS) is desired to overcome it. Hence, the potency of lipid-based nanoparticles encapsulating curcumin (LNPs-CUR) is considered in this study as a promising DDS. In vivo studies in animal models indicate LNPs-CUR effectively slow amyloid plaque formation, leading to cognitive enhancement and reduced toxicity compared to free CUR. However, a deeper understanding of CUR\'s pharmacokinetics and safety profile is crucial before LNPs-CUR can be considered as a medicine. Future investigations may explore the combination of NPs with other therapeutic agents to increase their efficacy in AD cases. This review provides the current position of CUR in the AD therapy paradigm, the DDS suggestions for CUR, and the previous research from the point of analytical view focused on the advantages and challenges.
摘要：
阿尔茨海默病（AD）是一种神经系统疾病，目前全球有4700万人患有这种疾病。AD可能有很多原因，比如遗传问题，环境因素,和Aβ积累，这是疾病的生物标志物。由于主要原因未知，目前没有针对性的治疗，但是正在进行的研究旨在通过控制淀粉样β肽的产生而不是症状改善来减缓其进展.由于植物化学物质已被证明具有抗氧化剂，抗炎,和神经保护特性，它们可能针对多种病理因素，并可以降低疾病的风险。姜黄素,作为姜黄中发现的一种植物化学物质，以其抗氧化剂而闻名，自由基清除性能，作为治疗AD的抗淀粉样蛋白，正在接受调查.尽管其生物利用度低限制了其疗效,需要一种突出的药物递送系统(DDS)来克服它。因此，在这项研究中，包封姜黄素的基于脂质的纳米颗粒（LNPs-CUR）的效力被认为是有前途的DDS。动物模型的体内研究表明，LNPs-CUR可有效减缓淀粉样蛋白斑块的形成，与游离CUR相比，导致认知增强和毒性降低。然而,在LNPs-CUR被认为是一种药物之前,更深入地了解CUR的药代动力学和安全性是至关重要的.未来的研究可能会探索NP与其他治疗剂的组合，以提高其在AD病例中的疗效。这篇综述提供了CUR在AD治疗范式中的当前地位，对CUR的DDS建议，以往的研究从分析的角度集中在优势和挑战。
