Abstract：
The SARS-CoV-2 virus is responsible for the human disease known as COVID-19. This virus is capable of generating a spectrum of infections ranging from moderate to severe. Serum apolipoprotein E (ApoE) inhibits inflammation by preserving immune regulatory function. Nonetheless, the relationship between serum ApoE and clinical prognosis in omicron remains elusive. A cohort of 231 patients was observed for 65 days, with death as the primary outcome. Based on their ApoE levels, the patients were categorized into patients with elevated ApoE levels and those with lower ApoE levels. To do statistical comparisons, the log-rank test was utilized, and the Kaplan-Meier method was utilized to estimate survival rates. Cox hazard models, both univariate and multivariate, were employed to examine the prognostic relevance. According to our research, omicron had significantly greater ApoE levels. In mild-to-moderate and severe cases, the study identified a statistically significant variation in ApoE levels. Additionally, there was a drop in overall survival that is statistically significant (OS, p < 0.0001) for patients with greater ApoE levels. Multiple Cox proportional hazards regression analysis indicates that an elevated ApoE level was determined to be an adverse and independent prognostic factor of OS in patients with omicron. Taken together, our study found that the level of serum ApoE at the time of initial diagnosis was substantially connected to the severity and prognosis of omicron. Consequently, we propose that ApoE might be a poor prognostic factor in individuals afflicted with the omicron variant.
摘要：
SARS-CoV-2病毒是导致人类疾病的原因，称为COVID-19。这种病毒能够产生从中度到重度的一系列感染。血清载脂蛋白E(ApoE)通过保持免疫调节功能抑制炎症。尽管如此，Omicron的血清ApoE与临床预后之间的关系仍然难以捉摸。一个由231名患者组成的队列观察了65天，以死亡为主要结果。根据他们的ApoE水平,将患者分为ApoE水平升高的患者和ApoE水平较低的患者.要进行统计比较，采用对数秩检验，并利用Kaplan-Meier方法估计生存率。Cox危险模型,单变量和多变量，用于检查预后相关性。根据我们的研究,omicron的ApoE水平明显更高。在轻度至中度和重度病例中，该研究确定了ApoE水平的统计学差异。此外,总生存率下降具有统计学意义(OS，p<0.0001）对于ApoE水平较高的患者。多重Cox比例风险回归分析表明，ApoE水平升高被确定为OS患者的不良和独立预后因素。一起来看,我们的研究发现,初次诊断时的血清ApoE水平与omicron的严重程度和预后密切相关.因此,我们认为，ApoE可能是患有omicron变异体的个体的不良预后因素。
