Abstract：
Despite advanced clinical treatment, the mortality rate of cancer patients is high. Recent studies have linked the development of cancer to inflammation. Many cancers are exacerbated by the emergence of inflammatory responses, and non-coding RNAs play an important role in inflammation. Non-coding RNAs include microRNAs, circular RNAs, long-chain noncoding RNAs, etc. The non-coding RNA regulatory network composed of microRNAs, circular RNAs and long-chain non-coding RNAs is involved in the regulatory process of multiple gene expression. They can act on various signaling pathways, such as wnt/β-catenin, nuclear factorkappa B, phosphatidylinositol 3 kinase/ AKT, mitogen-activated protein kinase, and so on. These signaling pathways can control the occurrence of inflammatory response to some extent, such as regulating the expression of inflammatory cytokines (such as interleukin-6, interferongamma, tumor necrosis factor-α, and so on), making them upregulated or down-regulated. Therefore, it is important to study the role of non-coding RNAs in inflammation to contribute to the future of cancer.
摘要：
尽管先进的临床治疗，癌症患者的死亡率很高。最近的研究将癌症的发展与炎症联系起来。炎症反应的出现加剧了许多癌症，和非编码RNA在炎症中起重要作用。非编码RNA包括microRNA,环状RNA，长链非编码RNA，等。由microRNAs组成的非编码RNA调控网络,环状RNA和长链非编码RNA参与多基因表达的调控过程。它们可以作用于各种信号通路，如wnt/β-catenin，核因子κB,磷脂酰肌醇3激酶/AKT,丝裂原活化蛋白激酶,等等。这些信号通路可以在一定程度上控制炎症反应的发生,如调节炎性细胞因子的表达(如白细胞介素-6，干扰素，肿瘤坏死因子-α，等等)，使它们上调或下调。因此,研究非编码RNA在炎症中的作用对癌症的未来有重要意义.
