Abstract：
OBJECTIVE: The aim of this prospective, single-center cohort study was to analyze serum leucine-rich α-2-glycoprotein-1 (LRG1) expression in patients with acute cholecystitis (AC) and to investigate its variation depending on symptom duration.
METHODS: Participants were divided into patients with AC and a healthy control group. At the time of diagnosis, blood samples were collected, and symptom onset times were questioned. Collected serum LRG1 levels were measured.
RESULTS: 30 patients and 30 healthy volunteers were included in the study. LRG1 (p=0.008), white blood cells (WBC) (p<0.001), platelet (p=0.003), neutrophil (p<0.001), lymphocyte (p=0.001), and CRP (p=0.014) were significantly different in AC patients vs. the control group. When the correlations of serum laboratory values with the time of onset of symptoms were compared, LRG1 (p<0.001) was significantly correlated, while no significant correlation was observed in C-reactive protein (CRP) (p=0.572), WBC (p=0.155), and neutrophil (p=0.155).
CONCLUSIONS: LRG1 expression increases after 24 hours in AC patients. Due to its correlation with symptom duration, we believe it can be helpful for timing cholecystectomy.
METHODS: Participants were divided into patients with AC and a healthy control group. At the time of diagnosis, blood samples were collected, and symptom onset times were questioned. Collected serum LRG1 levels were measured.
RESULTS: 30 patients and 30 healthy volunteers were included in the study. LRG1 (p=0.008), white blood cells (WBC) (p<0.001), platelet (p=0.003), neutrophil (p<0.001), lymphocyte (p=0.001), and CRP (p=0.014) were significantly different in AC patients vs. the control group. When the correlations of serum laboratory values with the time of onset of symptoms were compared, LRG1 (p<0.001) was significantly correlated, while no significant correlation was observed in C-reactive protein (CRP) (p=0.572), WBC (p=0.155), and neutrophil (p=0.155).
CONCLUSIONS: LRG1 expression increases after 24 hours in AC patients. Due to its correlation with symptom duration, we believe it can be helpful for timing cholecystectomy.
摘要：
目标：这个前瞻性的目标，单中心队列研究是分析急性胆囊炎（AC）患者血清富含亮氨酸的α-2-糖蛋白-1（LRG1）的表达，并研究其随症状持续时间的变化。
方法：将参与者分为AC患者和健康对照组。在诊断的时候,收集血样,和症状发作时间被质疑。测量收集的血清LRG1水平。
结果：30名患者和30名健康志愿者被纳入研究。LRG1（p=0.008），白细胞（WBC）（p<0.001），血小板（p=0.003），中性粒细胞（p<0.001），淋巴细胞（p=0.001），和CRP（p=0.014）在AC患者与对照组。当比较血清实验室值与症状发作时间的相关性时，LRG1(p<0.001)显著相关，而C反应蛋白（CRP）无显著相关性（p=0.572），白细胞（p=0.155），和中性粒细胞（p=0.155）。
结论：在AC患者中，LRG1表达在24小时后增加。由于其与症状持续时间的相关性，我们相信这对胆囊切除术的时机有帮助.
方法：将参与者分为AC患者和健康对照组。在诊断的时候,收集血样,和症状发作时间被质疑。测量收集的血清LRG1水平。
结果：30名患者和30名健康志愿者被纳入研究。LRG1（p=0.008），白细胞（WBC）（p<0.001），血小板（p=0.003），中性粒细胞（p<0.001），淋巴细胞（p=0.001），和CRP（p=0.014）在AC患者与对照组。当比较血清实验室值与症状发作时间的相关性时，LRG1(p<0.001)显著相关，而C反应蛋白（CRP）无显著相关性（p=0.572），白细胞（p=0.155），和中性粒细胞（p=0.155）。
结论：在AC患者中，LRG1表达在24小时后增加。由于其与症状持续时间的相关性，我们相信这对胆囊切除术的时机有帮助.
