PDF(Pubmed)
Abstract：
UNASSIGNED: It has been shown that autoimmune diseases are associated with psychiatric disorders in epidemiological studies. The acute psychiatric disorder patients have higher frequency of autoantibodies in the blood, including antinuclear antibodies, anti-thyroid peroxidase, and thyroglobulin [thyroid antibody carriers]. However, large clinical studies with more relevant control groups in China are few.
UNASSIGNED: This was a retrospective study. A total of 1669 sera were tested for autoantibodies in the clinical laboratory of the Fourth Affiliated Hospital, Zhejiang University School of Medicine from October 2016 to March 2021. All data available during this time period were analyzed. Only the first entry for each patient from inpatient care units was used for analysis. The clinical information and laboratory data of patients were retrospectively collected and analyzed.
UNASSIGNED: A significantly lower prevalence of antinuclear antibodies was observed in the healthy control group than in the patient group (21.7% vs 28.8%, P < .05). There was a significant difference in the prevalence of antinuclear antibodies between thyroglobulin-antibody carriers and thyroid peroxidase-antibody- and thyroglobulin-antibody-seronegative individuals in the unipolar depressive disorder group (P < .05). A positive anti-thyroid peroxidase test was significantly associated with patients having nonaffective psychoses (P < .05).
UNASSIGNED: The results showed that psychiatric disorders were associated with antinuclear antibodies and thyroid autoantibodies in our large sample of patients admitted to acute psychiatric hospitalization, and autoimmune autoantibodies were potential biomarkers of psychotic disorders. The results might lead to new research directions for the study of psychiatric disorders in the future.
UNASSIGNED: This was a retrospective study. A total of 1669 sera were tested for autoantibodies in the clinical laboratory of the Fourth Affiliated Hospital, Zhejiang University School of Medicine from October 2016 to March 2021. All data available during this time period were analyzed. Only the first entry for each patient from inpatient care units was used for analysis. The clinical information and laboratory data of patients were retrospectively collected and analyzed.
UNASSIGNED: A significantly lower prevalence of antinuclear antibodies was observed in the healthy control group than in the patient group (21.7% vs 28.8%, P < .05). There was a significant difference in the prevalence of antinuclear antibodies between thyroglobulin-antibody carriers and thyroid peroxidase-antibody- and thyroglobulin-antibody-seronegative individuals in the unipolar depressive disorder group (P < .05). A positive anti-thyroid peroxidase test was significantly associated with patients having nonaffective psychoses (P < .05).
UNASSIGNED: The results showed that psychiatric disorders were associated with antinuclear antibodies and thyroid autoantibodies in our large sample of patients admitted to acute psychiatric hospitalization, and autoimmune autoantibodies were potential biomarkers of psychotic disorders. The results might lead to new research directions for the study of psychiatric disorders in the future.
摘要：
■流行病学研究表明，自身免疫性疾病与精神疾病有关。急性精神疾病患者血液中自身抗体的发生率较高，包括抗核抗体,抗甲状腺过氧化物酶，和甲状腺球蛋白[甲状腺抗体携带者]。然而,在中国，具有更多相关对照组的大型临床研究很少。
■这是一项回顾性研究。共有1669份血清在附属第四医院的临床实验室进行了自身抗体检测,浙江大学医学院2016年10月至2021年3月。分析该时间段内所有可用的数据。仅使用来自住院护理单位的每位患者的第一个条目进行分析。对患者的临床资料和实验室资料进行回顾性分析。
■健康对照组的抗核抗体患病率明显低于患者组（21.7％vs28.8％，P<0.05)。在单相抑郁障碍组中，甲状腺球蛋白抗体携带者与甲状腺过氧化物酶抗体和甲状腺球蛋白抗体血清阴性个体之间的抗核抗体患病率存在显着差异（P<0.05）。抗甲状腺过氧化物酶检测阳性与非情感性精神病患者显著相关(P<0.05)。
■结果显示，在我们接受急性精神病住院的大样本患者中，精神疾病与抗核抗体和甲状腺自身抗体有关，自身免疫性自身抗体是精神障碍的潜在生物标志物.该结果可能为未来精神疾病的研究开辟新的研究方向。
■这是一项回顾性研究。共有1669份血清在附属第四医院的临床实验室进行了自身抗体检测,浙江大学医学院2016年10月至2021年3月。分析该时间段内所有可用的数据。仅使用来自住院护理单位的每位患者的第一个条目进行分析。对患者的临床资料和实验室资料进行回顾性分析。
■健康对照组的抗核抗体患病率明显低于患者组（21.7％vs28.8％，P<0.05)。在单相抑郁障碍组中，甲状腺球蛋白抗体携带者与甲状腺过氧化物酶抗体和甲状腺球蛋白抗体血清阴性个体之间的抗核抗体患病率存在显着差异（P<0.05）。抗甲状腺过氧化物酶检测阳性与非情感性精神病患者显著相关(P<0.05)。
■结果显示，在我们接受急性精神病住院的大样本患者中，精神疾病与抗核抗体和甲状腺自身抗体有关，自身免疫性自身抗体是精神障碍的潜在生物标志物.该结果可能为未来精神疾病的研究开辟新的研究方向。
