PDF(Pubmed)
Abstract：
Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are a type of stem cell that are only found inside the nervous system. These cells can differentiate into various kinds of cells, potentially regenerating or restoring neural networks within areas of the brain that have been destroyed. This review begins by providing an introduction to the existing therapeutic approaches for ischemic stroke, followed by an examination of the promise and limits associated with the utilization of NSCs for the treatment of ischemic stroke. Subsequently, a comprehensive overview was conducted to synthesize the existing literature on the underlying processes of neural stem cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy in the context of ischemic stroke. These mechanisms encompass neuroprotection, inflammatory response suppression, and endogenous nerve and vascular regeneration facilitation. Nevertheless, the clinical translation of NSC-sEVs is hindered by challenges such as inadequate targeting efficacy and insufficient content loading. In light of these limitations, we have compiled an overview of the advancements in utilizing modified NSC-sEVs for treating ischemic stroke based on current methods of extracellular vesicle modification. In conclusion, examining NSC-sEVs-based therapeutic approaches is anticipated to be prominent in both fundamental and applied investigations about ischemic stroke.
摘要：
缺血性中风,是全球残疾和死亡率的重要贡献者，在目前的临床环境中缺乏有效的治疗方法。神经干细胞（NSC）是一种仅在神经系统内部发现的干细胞。这些细胞可以分化成各种细胞，可能再生或恢复已被破坏的大脑区域内的神经网络。这篇综述首先介绍了缺血性卒中的现有治疗方法。随后检查与使用神经干细胞治疗缺血性卒中相关的前景和限制。随后，我们进行了全面的综述,综合了现有的关于神经干细胞来源的小细胞外囊泡(NSC-sEVs)移植治疗缺血性卒中的基础过程的文献.这些机制包括神经保护，炎症反应抑制，促进内源性神经和血管再生。然而，NSC-sEV的临床翻译受到靶向功效不足和内容物负荷不足等挑战的阻碍.鉴于这些限制,我们根据当前的细胞外囊泡修饰方法,对使用修饰的NSC-sEV治疗缺血性卒中的进展进行了综述.总之,研究基于NSC-sEV的治疗方法预计将在缺血性卒中的基础和应用研究中发挥重要作用.
