PDF(Pubmed)
Abstract：
Obesity is a heterogeneous condition which results from complex interactions among sex/gender, sociocultural, environmental, and biological factors. Obesity is more prevalent in women in most developed countries, and several clinical and psychological obesity complications show sex-specific patterns. Females differ regarding fat distribution, with males tending to store more visceral fat, which is highly correlated to increased cardiovascular risk. Although women are more likely to be diagnosed with obesity and appear more motivated to lose weight, as confirmed by their greater representation in clinical trials, males show better outcomes in terms of body weight and intra-abdominal fat loss and improvements in the metabolic risk profile. However, only a few relatively recent studies have investigated gender differences in obesity, and sex/gender is rarely considered in the assessment and management of the disease. This review summarizes the evidence of gender differences in obesity prevalence, contributing factors, clinical complications, and psychological challenges. In addition, we explored gender differences in response to obesity treatments in the specific context of new anti-obesity drugs.
摘要：
肥胖是由性别/性别之间复杂的相互作用引起的异质性疾病，社会文化,环境,和生物因素。在大多数发达国家，肥胖在女性中更为普遍，一些临床和心理肥胖并发症表现出性别特异性模式。女性在脂肪分布方面有所不同，男性倾向于储存更多的内脏脂肪，这与心血管风险增加高度相关。尽管女性更有可能被诊断为肥胖，并且似乎更有动力减肥，正如他们在临床试验中更大的代表性所证实的那样，男性在体重和腹内脂肪减少以及代谢风险状况改善方面表现出更好的结局.然而,只有少数相对较新的研究调查了肥胖的性别差异，在疾病的评估和管理中很少考虑性别。这篇综述总结了肥胖患病率的性别差异的证据，促成因素,临床并发症,心理挑战。此外,我们在新的抗肥胖药物的特定背景下探讨了肥胖治疗的性别差异.
