PDF(Pubmed)
Abstract：
UNASSIGNED: The presence of carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) around the world is increasing, particularly in healthcare settings. Surveillance testing for plasmid-mediated carbapenemase genes is necessary to tracking CP-CRE infections.
UNASSIGNED: In the state of Ohio, surveillance of carbapenem-resistant Enterobacterales (CRE) began in 2018, and to the authors\' knowledge data on these cases has not been published to date. This study analyzed data on CRE from a large teaching hospital in Ohio, and by the Ohio Department of Health Laboratory (ODHL).
UNASSIGNED: Carbapenemase production was detected using mCIM, and plasmid-mediated carbapenemase genes were detected using rtPCR. Data was collected on 344 standard-of-care isolates from a large teaching hospital in Ohio, including data collected from chart review. Deidentified surveillance data on 4,391 CRE isolates was provided by the ODHL. Statistical analysis was performed using binary logistic regression.
UNASSIGNED: While KPC was the most common carbapenemase gene (n=1590), NDM (n=98), VIM (n=10), IMP (n=39) and OXA-48 (n=35) were also detected in the isolates studied. Klebsiella pneumoniae and Enterobacter cloacae were the most common CRE, and carbapenemase genes were most commonly detected in K. pneumoniae. Inpatient hospital stays and long-term care were associated with CP-CRE and were more common in women.
UNASSIGNED: Surveillance data shows that CP-CRE are present in Ohio, most commonly in Klebsiella pneumoniae. A better understanding of the prevalence of CRE, plasmid-mediated carbapenemase genes present, and the populations affected are important when tracking the spread of disease. Further study and surveillance of carbapenem-resistant organisms can provide a better understanding of their prevalence in the state.
UNASSIGNED: In the state of Ohio, surveillance of carbapenem-resistant Enterobacterales (CRE) began in 2018, and to the authors\' knowledge data on these cases has not been published to date. This study analyzed data on CRE from a large teaching hospital in Ohio, and by the Ohio Department of Health Laboratory (ODHL).
UNASSIGNED: Carbapenemase production was detected using mCIM, and plasmid-mediated carbapenemase genes were detected using rtPCR. Data was collected on 344 standard-of-care isolates from a large teaching hospital in Ohio, including data collected from chart review. Deidentified surveillance data on 4,391 CRE isolates was provided by the ODHL. Statistical analysis was performed using binary logistic regression.
UNASSIGNED: While KPC was the most common carbapenemase gene (n=1590), NDM (n=98), VIM (n=10), IMP (n=39) and OXA-48 (n=35) were also detected in the isolates studied. Klebsiella pneumoniae and Enterobacter cloacae were the most common CRE, and carbapenemase genes were most commonly detected in K. pneumoniae. Inpatient hospital stays and long-term care were associated with CP-CRE and were more common in women.
UNASSIGNED: Surveillance data shows that CP-CRE are present in Ohio, most commonly in Klebsiella pneumoniae. A better understanding of the prevalence of CRE, plasmid-mediated carbapenemase genes present, and the populations affected are important when tracking the spread of disease. Further study and surveillance of carbapenem-resistant organisms can provide a better understanding of their prevalence in the state.
摘要：
■世界各地产生碳青霉烯酶的耐碳青霉烯类肠杆菌（CP-CRE）的存在正在增加，特别是在医疗机构。质粒介导的碳青霉烯酶基因的监测测试对于追踪CP-CRE感染是必要的。
■在俄亥俄州，碳青霉烯类耐药肠杆菌(CRE)的监测始于2018年,对于作者而言,迄今尚未公布这些病例的知识数据.这项研究分析了俄亥俄州一家大型教学医院的CRE数据，和俄亥俄州卫生部实验室（ODHL）。
■使用mCIM检测到碳青霉烯酶的产生，使用rtPCR检测质粒介导的碳青霉烯酶基因。数据来自俄亥俄州一家大型教学医院的344个标准护理分离株，包括从图表审查中收集的数据。ODHL提供了4,391个CRE分离株的鉴定监测数据。使用二元逻辑回归进行统计分析。
■虽然KPC是最常见的碳青霉烯酶基因（n=1590），NDM（n=98），VIM（n=10），在研究的分离物中还检测到IMP（n=39）和OXA-48（n=35）。肺炎克雷伯菌和阴沟肠杆菌是最常见的CRE，碳青霉烯酶基因在肺炎克雷伯菌中最常见。住院和长期护理与CP-CRE相关，在女性中更为常见。
■监视数据显示，CP-CRE存在于俄亥俄州，最常见于肺炎克雷伯菌。更好地了解CRE的患病率，质粒介导的碳青霉烯酶基因存在，在追踪疾病传播时，受影响的人群很重要。对碳青霉烯耐药生物的进一步研究和监测可以更好地了解其在该州的流行情况。
■在俄亥俄州，碳青霉烯类耐药肠杆菌(CRE)的监测始于2018年,对于作者而言,迄今尚未公布这些病例的知识数据.这项研究分析了俄亥俄州一家大型教学医院的CRE数据，和俄亥俄州卫生部实验室（ODHL）。
■使用mCIM检测到碳青霉烯酶的产生，使用rtPCR检测质粒介导的碳青霉烯酶基因。数据来自俄亥俄州一家大型教学医院的344个标准护理分离株，包括从图表审查中收集的数据。ODHL提供了4,391个CRE分离株的鉴定监测数据。使用二元逻辑回归进行统计分析。
■虽然KPC是最常见的碳青霉烯酶基因（n=1590），NDM（n=98），VIM（n=10），在研究的分离物中还检测到IMP（n=39）和OXA-48（n=35）。肺炎克雷伯菌和阴沟肠杆菌是最常见的CRE，碳青霉烯酶基因在肺炎克雷伯菌中最常见。住院和长期护理与CP-CRE相关，在女性中更为常见。
■监视数据显示，CP-CRE存在于俄亥俄州，最常见于肺炎克雷伯菌。更好地了解CRE的患病率，质粒介导的碳青霉烯酶基因存在，在追踪疾病传播时，受影响的人群很重要。对碳青霉烯耐药生物的进一步研究和监测可以更好地了解其在该州的流行情况。
