PDF(Pubmed)
Abstract：
The biological rhythm is a fundamental aspect of an organism, regulating many physiological processes. This study focuses on the analysis of the molecular basis of circadian rhythms and its impact on the functioning of the liver. The regulation of biological rhythms is carried out by the clock system, which consists of the central clock and peripheral clocks. The central clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus and is regulated by signals received from the retinal pathway. The SCN regulates the circadian rhythm of the entire body through its indirect influence on the peripheral clocks. In turn, the peripheral clocks can maintain their own rhythm, independent of the SCN, by creating special feedback loops between transcriptional and translational factors. The main protein families involved in these processes are CLOCK, BMAL, PER and CRY. Disorders in the expression of these factors have a significant impact on the functioning of the liver. In such cases lipid metabolism, cholesterol metabolism, bile acid metabolism, alcohol metabolism, and xenobiotic detoxification can be significantly affected. Clock dysfunctions contribute to the pathogenesis of various disorders, including fatty liver disease, liver cirrhosis and different types of cancer. Therefore understanding circadian rhythm can have significant implications for the therapy of many liver diseases, as well as the development of new preventive and treatment strategies.
摘要：
生物节律是生物体的一个基本方面，调节许多生理过程。这项研究的重点是分析昼夜节律的分子基础及其对肝脏功能的影响。生物节律的调节是由时钟系统进行的，它由中央时钟和外围时钟组成。中心时钟位于下丘脑的视交叉上核（SCN）中，并由从视网膜通路接收的信号调节。SCN通过其对外围时钟的间接影响来调节整个身体的昼夜节律。反过来,外围时钟可以保持自己的节奏，独立于SCN，通过在转录和翻译因子之间创建特殊的反馈回路。参与这些过程的主要蛋白质家族是CLOCK，BMAL,和哭泣。这些因子表达的紊乱对肝脏的功能有显著影响。在这种情况下，脂质代谢，胆固醇代谢，胆汁酸代谢，酒精代谢，和异种生物的排毒可能会受到显著影响。时钟功能障碍有助于各种疾病的发病机理，包括脂肪肝,肝硬化和不同类型的癌症。因此，了解昼夜节律可以对许多肝病的治疗具有重要意义。以及开发新的预防和治疗策略。
