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Abstract：
UNASSIGNED: To investigate the association of smoking cessation intention and single nucleotide polymorphism of HDAC9 gene with LAA-S in Han people in Hainan province.
UNASSIGNED: A case-control study was conducted. Six single nucleotide polymorphisms (SNPS) of HDAC9 gene were genotyped by SNPscan genotyping technique in 248 patients with LAA-S and 237 controls in Hainan Han population. SNP loci (rs10227612, rs12669496, rs1548577, rs2074633, rs2526626, and rs2717344) were genotyped, and the genotype and allele frequencies were compared between the case and control group. At the same time, the distribution of smoking between the case and control group was compared, and the 3-year and 7-year follow-up smoking cessation between the case and control group was compared, so as to find out the effects of smoking cessation intention and HDAC9 SNP on LAA-S.
UNASSIGNED: (1) The GT genotype at rs10227612, GG genotype at rs2717344, and GA genotype at rs1548577 in the case group were significantly higher than those in the control group, and the differences were statistically significant. (2) There were significant differences in the distribution of smoking between the case and control group (P < 0.05), and there were significant differences in the smoking cessation after 3 years and 7 years of follow-up between the case and control group (P < 0.05). The intention to quit smoking was positively correlated with the incidence of LAA-S.
UNASSIGNED: (1) The rs10227612, rs1548577, rs2074633, rs2717344 of HDAC9 gene may be significantly related to atherosclerotic cerebral infarction of great arteries in Hainan Han population, while rs12669496 and rs2526626 may not be related. (2) According to the statistics of smoking in the case and control group, smoking was related to large artery atherosclerotic cerebral infarction, and the intention to quit smoking was a very important factor affecting the success of smoking cessation.
UNASSIGNED: A case-control study was conducted. Six single nucleotide polymorphisms (SNPS) of HDAC9 gene were genotyped by SNPscan genotyping technique in 248 patients with LAA-S and 237 controls in Hainan Han population. SNP loci (rs10227612, rs12669496, rs1548577, rs2074633, rs2526626, and rs2717344) were genotyped, and the genotype and allele frequencies were compared between the case and control group. At the same time, the distribution of smoking between the case and control group was compared, and the 3-year and 7-year follow-up smoking cessation between the case and control group was compared, so as to find out the effects of smoking cessation intention and HDAC9 SNP on LAA-S.
UNASSIGNED: (1) The GT genotype at rs10227612, GG genotype at rs2717344, and GA genotype at rs1548577 in the case group were significantly higher than those in the control group, and the differences were statistically significant. (2) There were significant differences in the distribution of smoking between the case and control group (P < 0.05), and there were significant differences in the smoking cessation after 3 years and 7 years of follow-up between the case and control group (P < 0.05). The intention to quit smoking was positively correlated with the incidence of LAA-S.
UNASSIGNED: (1) The rs10227612, rs1548577, rs2074633, rs2717344 of HDAC9 gene may be significantly related to atherosclerotic cerebral infarction of great arteries in Hainan Han population, while rs12669496 and rs2526626 may not be related. (2) According to the statistics of smoking in the case and control group, smoking was related to large artery atherosclerotic cerebral infarction, and the intention to quit smoking was a very important factor affecting the success of smoking cessation.
摘要：
■探讨海南汉族人群戒烟意向及HDAC9基因单核苷酸多态性与LAA-S的关系。
■进行了病例对照研究。采用SNPscan基因分型技术对248例LAA-S患者和237例海南汉族人群中HDAC9基因的6个单核苷酸多态性(SNPS)进行基因分型。对SNP基因座(rs10227612、rs12669496、rs1548577、rs2074633、rs2526626和rs2717344)进行基因分型,比较病例组和对照组的基因型和等位基因频率。同时,比较病例组和对照组的吸烟分布情况,并比较病例组和对照组3年和7年戒烟随访情况,从而了解戒烟意向和HDAC9SNP对LAA-S的影响。
■（1）病例组rs10227612的GT基因型，rs2717344的GG基因型和rs1548577的GA基因型明显高于对照组，差异有统计学意义。(2)病例组与对照组吸烟分布差异有统计学意义(P<0.05),随访3年和7年后戒烟情况与对照组比较差异均有统计学意义(P<0.05)。戒烟意向与LAA-S的发生率呈正相关。
■(1)HDAC9基因rs10227612、rs1548577、rs2074633、rs2717344可能与海南汉族人群大动脉粥样硬化性脑梗死有显著关系,而rs12669496和rs2526626可能不相关。(2)根据病例组和对照组的吸烟情况统计,吸烟与大动脉粥样硬化性脑梗死有关,戒烟意愿是影响戒烟成功的重要因素。
■进行了病例对照研究。采用SNPscan基因分型技术对248例LAA-S患者和237例海南汉族人群中HDAC9基因的6个单核苷酸多态性(SNPS)进行基因分型。对SNP基因座(rs10227612、rs12669496、rs1548577、rs2074633、rs2526626和rs2717344)进行基因分型,比较病例组和对照组的基因型和等位基因频率。同时,比较病例组和对照组的吸烟分布情况,并比较病例组和对照组3年和7年戒烟随访情况,从而了解戒烟意向和HDAC9SNP对LAA-S的影响。
■（1）病例组rs10227612的GT基因型，rs2717344的GG基因型和rs1548577的GA基因型明显高于对照组，差异有统计学意义。(2)病例组与对照组吸烟分布差异有统计学意义(P<0.05),随访3年和7年后戒烟情况与对照组比较差异均有统计学意义(P<0.05)。戒烟意向与LAA-S的发生率呈正相关。
■(1)HDAC9基因rs10227612、rs1548577、rs2074633、rs2717344可能与海南汉族人群大动脉粥样硬化性脑梗死有显著关系,而rs12669496和rs2526626可能不相关。(2)根据病例组和对照组的吸烟情况统计,吸烟与大动脉粥样硬化性脑梗死有关,戒烟意愿是影响戒烟成功的重要因素。
