PDF(Pubmed)
Abstract：
Calciphylaxis is a unique medical condition characterized by calcification of the medial layer of arterioles and soft tissues in a patient\'s skin at the level of the dermis and subcutaneous adipose tissue. The rate of progression of calciphylaxis is rapid, starting with a reduction of blood flow that leads to ischemic changes in the skin that can manifest as painful cutaneous erythematous nodules or plaques and later as skin ulceration. The majority of patients affected by calciphylaxis have predisposing comorbidities such as end-stage renal disease with a long history of hemodialysis and electrolyte abnormalities in calcium, phosphate, and parathyroid hormone levels. This report presents the case of a 72-year-old female patient on hemodialysis who developed calciphylaxis. The methods for early prognosis (the methods of early diagnosis), including clinical presentation, risk factors, imaging techniques, and laboratory investigations, are discussed. The presented case is particularly noteworthy given the onset of calciphylaxis within a mere three months of initiating hemodialysis, a timeline significantly shorter than the typically observed period in most patients. (The case detailed in this report outlines the rapid onset of calciphylaxis in a patient who was receiving hemodialysis for only three months.) This patient with early-onset calciphylaxis highlights the unpredictable nature of calciphylaxis and the need for increased clinical vigilance even in the initial stages of hemodialysis.
摘要：
钙化是一种独特的医学病症，其特征是患者皮肤中真皮和皮下脂肪组织水平的小动脉和软组织的中间层钙化。钙化的进展速度很快，从血流量减少开始，导致皮肤缺血性变化，可表现为疼痛的皮肤红斑结节或斑块，后来表现为皮肤溃疡。大多数受钙化影响的患者有易感的合并症，如终末期肾病，长期血液透析和钙电解质异常，磷酸盐,甲状旁腺激素水平.本报告介绍了一名72岁的血液透析女性患者发生钙化的情况。早期预后的方法（早期诊断的方法），包括临床表现，危险因素，成像技术，和实验室调查，正在讨论。鉴于在开始血液透析的仅仅三个月内就出现了钙化，因此该病例尤其值得注意。在大多数患者中，时间线明显短于通常观察到的时间段。（本报告中详细介绍的病例概述了仅接受血液透析三个月的患者中钙化的快速发作。）这位患有早发性钙化病的患者强调了钙化病的不可预测性质，即使在血液透析的初始阶段，也需要提高临床警惕性。
