PDF(Pubmed)
Abstract：
In the last ten years, there has been a notable rise in the study of metabolic abnormalities in cancer cells. However, compared to glucose or glutamine metabolism, less attention has been paid to the importance of lipid metabolism in tumorigenesis. Recent developments in lipidomics technologies have allowed for detailed analysis of lipid profiles within cancer cells and other cellular players present within the tumor microenvironment (TME). Traditional Chinese medicine (TCM) and its bioactive components have a long history of use in cancer treatments and are also being studied for their potential role in regulating metabolic reprogramming within TME. This review focuses on four core abnormalities altered by lipid reprogramming in cancer cells: de novo synthesis and exogenous uptake of fatty acids (FAs), upregulated fatty acid oxidation (FAO), cholesterol accumulation, which offer benefits for tumor growth and metastasis. The review also discusses how altered lipid metabolism impacts infiltrating immune cell function and phenotype as these interactions between cancer-stromal become more pronounced during tumor progression. Finally, recent literature is highlighted regarding how cancer cells can be metabolically reprogrammed by specific Chinese herbal components with potential therapeutic benefits related to lipid metabolic and signaling pathways.
摘要：
在过去的十年里，对癌细胞代谢异常的研究有了显著的增长。然而,与葡萄糖或谷氨酰胺代谢相比，脂质代谢在肿瘤发生中的重要性受到关注较少。脂质组学技术的最新发展允许详细分析癌细胞和肿瘤微环境（TME）中存在的其他细胞参与者内的脂质分布。中药（TCM）及其生物活性成分在癌症治疗中具有悠久的使用历史，并且在TME中调节代谢重编程的潜在作用也正在研究中。这篇综述集中在癌细胞中通过脂质重编程改变的四个核心异常：从头合成和脂肪酸（FAs）的外源摄取，上调脂肪酸氧化(FAO)，胆固醇积累，为肿瘤生长和转移提供益处。该综述还讨论了脂质代谢改变如何影响浸润性免疫细胞功能和表型，因为这些癌症-基质之间的相互作用在肿瘤进展期间变得更加明显。最后,最近的文献重点介绍了癌细胞如何通过特定的中草药成分进行代谢重编程,这些成分具有与脂质代谢和信号通路相关的潜在治疗益处.
