PDF(Pubmed)
Abstract：
In the study by Wu et al, patients with unresectable hepatocellular carcinoma were subjected to transarterial chemoembolization (TACE) as a conversion therapy in order to render their tumors suitable for resection. A nomogram was devised and shown to be effective in predicting the survival of these patients. Generalization of the results, however, is questionable since the study subjects consisted of patients who had resection after TACE while excluding patients with the same disease but not suitable for TACE. Immunotherapy can be considered to be an option for conversion therapy. However, markers for determining responses to a conversion therapy and for guiding the decision between TACE and sequential immunotherapy have been lacking. The question of whether effective conversion therapy can truly enhance overall survival remains unanswered.
摘要：
在Wu等人的研究中，无法切除的肝细胞癌患者接受经动脉化疗栓塞(TACE)作为转化治疗,以使其肿瘤适合切除.设计了列线图，并证明可有效预测这些患者的生存率。结果的推广，然而,这是值得怀疑的,因为研究对象包括在TACE后接受了手术切除的患者,同时排除了患有相同疾病但不适合TACE的患者.免疫疗法可以被认为是转换疗法的一种选择。然而,目前缺乏用于确定对转换治疗的反应以及指导TACE和序贯免疫疗法之间决定的标志物.有效的转化疗法是否可以真正提高总体生存率的问题仍然没有答案。
