UNASSIGNED: To determine the prevalence of EIMs and their most common types among IBD patients from Saudi Arabia.
UNASSIGNED: This retrospective study included all IBD patients aged 14-80 years who visited the Gastroenterology and Hepatology clinics at King Fahad Medical City, Riyadh, between February 2017 and December 2022. The collected data included demographic characteristics, disease characteristics, EIMs, and treatment.
UNASSIGNED: The study included 578 IBD patients, of which 65 (11.2%) had at least one EIM, with primary sclerosing cholangitis (46.2%) and sacroiliitis (16.9%) being the most common. Patients with ulcerative colitis were more likely to have EIMs than those with Crohn\'s disease (15.1% vs. 9%; P = 0.026). Patients with ileocolonic (L3) Crohn\'s disease reported a higher prevalence of EIMs (7.5%) than those with other disease locations (P = 0.012), while in patients with ulcerative colitis, those with extensive colitis (E3) reported higher prevalence of EIMs (19.2%) (P = 0.001). Patients receiving 6 MP had a significantly high prevalence of EIMs (P = 0.014).
UNASSIGNED: The prevalence of extraintestinal manifestations among IBD patients in Saudi Arabia is 11.2%. These findings suggest the need for clinicians to screen for EIMs and manage them early. Further research is needed to understand the mechanisms underlying EIMs for the development of more effective treatments.
■确定沙特阿拉伯IBD患者中EIM的患病率及其最常见的类型。
这项回顾性研究包括所有14-80岁的IBD患者,他们在法哈德国王医疗城的胃肠病和肝病诊所就诊,利雅得,2017年2月至2022年12月。收集的数据包括人口统计特征,疾病特征,EIM,和治疗。
■该研究包括578例IBD患者,其中65人(11.2%)至少有一个EIM,以原发性硬化性胆管炎(46.2%)和骶髂关节炎(16.9%)最为常见。溃疡性结肠炎患者比克罗恩病患者更容易发生EIM(15.1%vs.9%;P=0.026)。回肠结肠(L3)克罗恩病患者报告的EIMs患病率(7.5%)高于其他疾病位置(P=0.012),而在溃疡性结肠炎患者中,广泛性结肠炎(E3)患者的EIMs患病率较高(19.2%)(P=0.001).接受6例MP的患者EIM的患病率明显较高(P=0.014)。
■沙特阿拉伯IBD患者的肠外表现患病率为11.2%。这些发现表明,临床医生需要筛查EIM并尽早对其进行管理。需要进一步的研究来了解EIM的潜在机制,以开发更有效的治疗方法。