PDF(Pubmed)
Abstract：
Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is increasingly used for a diverse range of wounds. Meanwhile, the topical wound irrigation solution consisting of polyhexamethylene biguanide and betaine (PHMB-B) has shown efficacy in managing wound infections. However, the effectiveness of this solution as a topical instillation solution for NPWTi-d in patients with diabetic foot infections (DFIs) has not been thoroughly studied. The objective of this retrospective study was to evaluate the impact of using PHMB-B as the instillation solution during NPWTi-d on reducing bioburden and improving clinical outcomes in patients with DFIs. Between January 2017 and December 2022, a series of patients with DFIs received treatment with NPWTi-d, using either PHMB-B or normal saline as the instillation solution. Data collected retrospectively included demographic information, baseline wound characteristics, and treatment outcomes. The study included 61 patients in the PHMB-B group and 73 patients in the normal saline group, all diagnosed with DFIs. In comparison to patients treated with normal saline, patients with PHMB-B exhibited no significant differences in terms of wound bed preparation time (P = 0.5034), length of hospital stay (P = 0.6783), NPWTi-d application times (P = 0.1458), duration of systematic antimicrobial administration (P = 0.3567), or overall cost of hospitalization (P = 0.6713). The findings of the study suggest that the use of either PHMB-B or normal saline as an instillation solution in NPWTi-d for DFIs shows promise and effectiveness, yet no clinical distinction was observed between the two solutions.
摘要：
具有滴注和停留时间的负压伤口疗法（NPWTi-d）越来越多地用于各种范围的伤口。同时,由聚六亚甲基双胍和甜菜碱（PHMB-B）组成的局部伤口冲洗溶液已显示出治疗伤口感染的功效。然而,该溶液作为糖尿病足感染(DFIs)患者NPWTi-d局部滴注溶液的有效性尚未得到彻底研究.这项回顾性研究的目的是评估在NPWTi-d期间使用PHMB-B作为滴注溶液对降低DFI患者的生物负载和改善临床结果的影响。在2017年1月至2022年12月期间，一系列DFI患者接受了NPWTi-d治疗，使用PHMB-B或生理盐水作为滴注溶液。回顾性收集的数据包括人口统计信息，基线伤口特征，和治疗结果。该研究包括PHMB-B组61例患者和生理盐水组73例患者。都被诊断为DFI。与用生理盐水治疗的患者相比，PHMB-B患者的创床准备时间无显著差异(P=0.5034),住院时间（P=0.6783），NPWTi-d应用次数(P=0.1458)，系统性抗菌药物给药持续时间（P=0.3567），或住院总费用（P=0.6713）。研究结果表明，使用PHMB-B或生理盐水作为DFI的NPWTi-d滴注溶液显示出希望和有效性。然而，在两种解决方案之间没有观察到临床区别。
