Abstract：
BACKGROUND: Septic shock is a lethal disease, and identifying high-risk patients through noninvasive and widely available biomarkers can help improve global outcomes. While the clinical impact of chloride levels on critically ill patients remains unclear, this study aims to investigate the association between hypochloremia and mortality following ICU admission among septic shock patients.
METHODS: This is an analysis of data stored in the databases of Medical Information Mart for Intensive Care IV (MIMIC-IV). The initial chloride levels were classified ashypochloremia, normal chloraemia, and hyperchloraemia. A multivariate logistic regression model was applied, adjusting for age, lactate, pH, PO2, urine volume, RDW, creatinine, and liver disease, to assess the association between the three categories of chloride levels and mortality.
RESULTS: Of 3726 patients included in the study, 470 patients (12.6%) had hypochloremia on ICU admission. During the follow-up period, 1120 (33.5%) patients died. Hypochloremia was significantly associated with increased mortality and the incidence of AKI after adjusting for several variables.
CONCLUSIONS: Hypochloremia is independently associated with higher hospital mortality, AKI incidence among septic shock patients. However, further high-quality research is necessary to establish the precise relationship between hypochloremia and septic shock prognosis.
METHODS: This is an analysis of data stored in the databases of Medical Information Mart for Intensive Care IV (MIMIC-IV). The initial chloride levels were classified ashypochloremia, normal chloraemia, and hyperchloraemia. A multivariate logistic regression model was applied, adjusting for age, lactate, pH, PO2, urine volume, RDW, creatinine, and liver disease, to assess the association between the three categories of chloride levels and mortality.
RESULTS: Of 3726 patients included in the study, 470 patients (12.6%) had hypochloremia on ICU admission. During the follow-up period, 1120 (33.5%) patients died. Hypochloremia was significantly associated with increased mortality and the incidence of AKI after adjusting for several variables.
CONCLUSIONS: Hypochloremia is independently associated with higher hospital mortality, AKI incidence among septic shock patients. However, further high-quality research is necessary to establish the precise relationship between hypochloremia and septic shock prognosis.
摘要：
背景：感染性休克是一种致命疾病，通过非侵入性和广泛可用的生物标志物识别高危患者有助于改善全球结局。虽然氯化物水平对危重病患者的临床影响尚不清楚，本研究旨在探讨感染性休克患者入住ICU后低氯血症与死亡率之间的关系.
方法：这是对重症监护医学信息集市（MIMIC-IV）数据库中存储的数据的分析。最初的氯化物水平被归类为低氯血症，正常的氯血症,和高氯血症.应用多元逻辑回归模型，调整年龄，乳酸，pH值,PO2，尿量，RDW,肌酐,和肝脏疾病，评估三类氯化物水平与死亡率之间的关系。
结果：在纳入研究的3726名患者中，470例(12.6%)患者入住ICU时出现低氯血症。在后续期间,1120例（33.5%）患者死亡。在调整了几个变量后，低氯血症与死亡率和AKI发生率的增加显着相关。
结论：低氯血症与较高的住院死亡率独立相关，感染性休克患者的AKI发生率。然而,进一步的高质量研究需要建立低氯血症与感染性休克预后之间的精确关系。
方法：这是对重症监护医学信息集市（MIMIC-IV）数据库中存储的数据的分析。最初的氯化物水平被归类为低氯血症，正常的氯血症,和高氯血症.应用多元逻辑回归模型，调整年龄，乳酸，pH值,PO2，尿量，RDW,肌酐,和肝脏疾病，评估三类氯化物水平与死亡率之间的关系。
结果：在纳入研究的3726名患者中，470例(12.6%)患者入住ICU时出现低氯血症。在后续期间,1120例（33.5%）患者死亡。在调整了几个变量后，低氯血症与死亡率和AKI发生率的增加显着相关。
结论：低氯血症与较高的住院死亡率独立相关，感染性休克患者的AKI发生率。然而,进一步的高质量研究需要建立低氯血症与感染性休克预后之间的精确关系。
