PDF(Pubmed)
Abstract：
UNASSIGNED: Intrathyroid thymic carcinoma (ITC) is a malignant epithelial tumor with thymic differentiation within the thyroid gland. Its frequency is up to 0.15 % of all malignant thyroid tumors. It is frequently a low-grade tumor. The clinical status is often misleading to other more advanced tumors like cervical lymph node metastasis of nonkeratinizing squamous cell carcinoma, undifferentiated variant, dedifferentiated carcinoma, and medullary carcinoma of the thyroid.
UNASSIGNED: The patient came to us with the diagnosis of cervical lymph node metastasis of undifferentiated carcinoma. This patient was first diagnosed with cervical lymph node metastasis in the previous hospital. After having an ITC diagnosis, the patient was operated on the rennet of thyroid glands and had a low dose of radio-chemotherapy for recurrent prevention purposes. It is the first case of such a disease diagnosed at our hospital and also the first case reported in Vietnam.
UNASSIGNED: ITC is rare and appears similar to all thymic carcinoma variants. The most popular type is squamous carcinoma. Immunohistochemical stains are typical for thymic origin tumors with CD5, CD117 positive. ITC is often negative for monoclonal PAX8 but positive in this case (MRQ-50 clone, Sigma-Aldrich). This finding is an exciting one that should considered.
CONCLUSIONS: Reporting the case increases the awareness of the disease, especially among Vietnam Doctors and patients.
UNASSIGNED: The patient came to us with the diagnosis of cervical lymph node metastasis of undifferentiated carcinoma. This patient was first diagnosed with cervical lymph node metastasis in the previous hospital. After having an ITC diagnosis, the patient was operated on the rennet of thyroid glands and had a low dose of radio-chemotherapy for recurrent prevention purposes. It is the first case of such a disease diagnosed at our hospital and also the first case reported in Vietnam.
UNASSIGNED: ITC is rare and appears similar to all thymic carcinoma variants. The most popular type is squamous carcinoma. Immunohistochemical stains are typical for thymic origin tumors with CD5, CD117 positive. ITC is often negative for monoclonal PAX8 but positive in this case (MRQ-50 clone, Sigma-Aldrich). This finding is an exciting one that should considered.
CONCLUSIONS: Reporting the case increases the awareness of the disease, especially among Vietnam Doctors and patients.
摘要：
■甲状腺内胸腺癌（ITC）是甲状腺内胸腺分化的恶性上皮性肿瘤。它的频率高达所有恶性甲状腺肿瘤的0.15％。它通常是低度肿瘤。临床状况通常会误导其他更晚期的肿瘤，如非角化鳞状细胞癌的颈淋巴结转移，未分化变体，去分化癌,甲状腺髓样癌.
■患者诊断为未分化癌的颈淋巴结转移。该患者在以前的医院首次诊断为颈淋巴结转移。在做了ITC诊断后,该患者接受了甲状腺凝乳酶手术，并接受了低剂量的放化疗以预防复发。这是我们医院诊断出的首例此类疾病，也是越南报告的首例病例。
■ITC是罕见的，似乎与所有胸腺癌变体相似。最流行的类型是鳞癌。免疫组织化学染色对于具有CD5、CD117阳性的胸腺起源肿瘤是典型的。ITC通常对单克隆PAX8呈阴性，但在这种情况下呈阳性（MRQ-50克隆，Sigma-Aldrich）。这个发现是一个令人兴奋的，应该考虑。
结论：报告病例增加了对该疾病的认识，尤其是在越南医生和患者中。
■患者诊断为未分化癌的颈淋巴结转移。该患者在以前的医院首次诊断为颈淋巴结转移。在做了ITC诊断后,该患者接受了甲状腺凝乳酶手术，并接受了低剂量的放化疗以预防复发。这是我们医院诊断出的首例此类疾病，也是越南报告的首例病例。
■ITC是罕见的，似乎与所有胸腺癌变体相似。最流行的类型是鳞癌。免疫组织化学染色对于具有CD5、CD117阳性的胸腺起源肿瘤是典型的。ITC通常对单克隆PAX8呈阴性，但在这种情况下呈阳性（MRQ-50克隆，Sigma-Aldrich）。这个发现是一个令人兴奋的，应该考虑。
结论：报告病例增加了对该疾病的认识，尤其是在越南医生和患者中。
