CBL 和 CBLB 泛素连接酶的缺乏通过减少 BCL6 降解导致高 T 滤泡辅助细胞反应和狼疮。
关键词: BCL6 CBL family proteins CMA ICOS SLE Tfh chaperone-mediated autophagy follicular helper T cell systemic lupus erythematosus ubiquitination
Mesh : Animals Female Humans Mice Adaptor Proteins, Signal Transducing / metabolism genetics Autophagy / immunology Inducible T-Cell Co-Stimulator Protein / metabolism genetics Lupus Erythematosus, Systemic / immunology genetics Mice, Inbred C57BL Mice, Knockout Proteolysis Proto-Oncogene Proteins c-bcl-6 / metabolism genetics Proto-Oncogene Proteins c-cbl / metabolism genetics deficiency Signal Transduction / immunology T Follicular Helper Cells / immunology T-Lymphocytes, Helper-Inducer / immunology Ubiquitination
来 源: DOI:10.1016/j.immuni.2024.04.023