Abstract：
Staphylococcus aureus is a significant bacterium responsible for multiple infections and is a primary cause of fatalities among patients in hospital environments. The advent of pathogenic bacteria such as methicillin-resistant S. aureus revealed the shortcomings of employing antibiotics to treat bacterial infectious diseases. Quorum sensing enhances S. aureus\'s survivability through signaling processes. Targeting the key components of quorum sensing has drawn much interest nowadays as a promising strategy for combating infections caused by bacteria. Concentrating on the accessory gene regulator quorum-sensing mechanism is the most commonly suggested anti-virulence approach for S.aureus. Quorum quenching is a common strategy for controlling illnesses triggered by microorganisms since it reduces the pathogenicity of bacteria and improves bacterial biofilm susceptibility to antibiotics, thus providing an intriguing prospect for drug discovery. Quorum sensing inhibition reduces selective stresses and constrains the emergence of antibiotic resistance while limiting bacterial pathogenicity. This review examines the quorum sensing mechanisms involved in S. aureus, quorum sensing targets and gene regulation, environmental factors affecting quorum sensing, quorum sensing inhibition, natural products as quorum sensing inhibitory agents and novel therapeutical strategies to target quorum sensing in S. aureus as drug developing technique to augment conventional antibiotic approaches.
摘要：
金黄色葡萄球菌是引起多种感染的重要细菌，并且是医院环境中患者死亡的主要原因。诸如耐甲氧西林金黄色葡萄球菌的致病细菌的出现揭示了使用抗生素治疗细菌感染性疾病的缺点。群体感应通过信号传导过程增强金黄色葡萄球菌的生存能力。如今，针对群体感应的关键组成部分作为对抗细菌引起的感染的有希望的策略引起了人们的极大兴趣。专注于辅助基因调节因子群体感应机制是金黄色葡萄球菌最常用的抗毒力方法。群体淬灭是控制由微生物引发的疾病的常见策略，因为它降低了细菌的致病性并提高了细菌生物膜对抗生素的敏感性。从而为药物发现提供了一个有趣的前景。群体感应抑制减少选择性应激并限制抗生素抗性的出现,同时限制细菌致病性。这篇综述探讨了金黄色葡萄球菌的群体感应机制，群体感应靶标和基因调控，影响群体感应的环境因素，群体感应抑制，天然产物作为群体感应抑制剂，以及靶向金黄色葡萄球菌群体感应的新型治疗策略，作为药物开发技术来增强常规抗生素方法。
