PDF(Pubmed)
Abstract：
BACKGROUND: Lateral lymph node dissection (LLND) for rectal cancer is still not a widely established technique owing to the existing controversy between Eastern and Western countries and the lack of well-designed studies. The risk of complications and the paucity of long-term oncological results are significant drawbacks for further applying this technique. The use of indocyanine green (ICG) near-infrared (NIR) fluorescence for LLND appears as a promising technique for enhancing postoperative and oncological outcomes. This review aims to evaluate the emerging role of ICG during LLND and present the benefits of its application.
METHODS: Systematic electronic research was conducted in PubMed and Google Scholar using a combination of medical subject headings (MeSH). Studies presenting the use of ICG during LLND, especially in terms of harvested lymph nodes, were included and reviewed. Studies comparing LLND with ICG (LLND + ICG) or without ICG (LLND-alone) were further analyzed for the number of lymph nodes and postoperative outcomes.
RESULTS: In total, 13 studies were found eligible and analyzed for different parameters. LLND + ICG is associated with significantly increased number of harvested lateral lymph nodes (p < 0.05), minor blood loss, decreased operative time, and probably decreased urinary retention postoperatively compared with LLND-alone.
CONCLUSIONS: The use of ICG fluorescence during LLND is a safe and feasible technique for balancing postoperative outcomes and the number of harvested lymph nodes. Well-designed studies with long-term results are required to elucidate the oncological benefits and establish this promising technique.
METHODS: Systematic electronic research was conducted in PubMed and Google Scholar using a combination of medical subject headings (MeSH). Studies presenting the use of ICG during LLND, especially in terms of harvested lymph nodes, were included and reviewed. Studies comparing LLND with ICG (LLND + ICG) or without ICG (LLND-alone) were further analyzed for the number of lymph nodes and postoperative outcomes.
RESULTS: In total, 13 studies were found eligible and analyzed for different parameters. LLND + ICG is associated with significantly increased number of harvested lateral lymph nodes (p < 0.05), minor blood loss, decreased operative time, and probably decreased urinary retention postoperatively compared with LLND-alone.
CONCLUSIONS: The use of ICG fluorescence during LLND is a safe and feasible technique for balancing postoperative outcomes and the number of harvested lymph nodes. Well-designed studies with long-term results are required to elucidate the oncological benefits and establish this promising technique.
摘要：
背景：由于东西方国家之间存在争议以及缺乏精心设计的研究，直肠癌的侧淋巴结清扫术（LLND）仍然不是一种广泛建立的技术。并发症的风险和长期肿瘤结果的缺乏是进一步应用该技术的重大缺点。使用吲哚菁绿（ICG）近红外（NIR）荧光进行LLND似乎是增强术后和肿瘤学结果的有希望的技术。这篇综述旨在评估ICG在LLND期间的新兴作用，并介绍其应用的好处。
方法：在PubMed和GoogleScholar中使用医学主题词（MeSH）的组合进行了系统的电子研究。介绍在LLND期间使用ICG的研究，特别是在收集的淋巴结方面，包括在内并进行了审查。比较LLND与ICG(LLND+ICG)或无ICG(LLND-单独)的研究进一步分析淋巴结数目和术后结果。
结果：总计，发现13项研究合格，并分析了不同的参数。LLND+ICG与收集的外侧淋巴结数量显着增加有关（p<0.05），轻微失血,减少手术时间，与单用LLND相比，术后尿潴留可能减少。
结论：在LLND期间使用ICG荧光是平衡术后结果和收集的淋巴结数量的安全可行的技术。需要精心设计的具有长期结果的研究来阐明肿瘤学益处并建立这种有前途的技术。
方法：在PubMed和GoogleScholar中使用医学主题词（MeSH）的组合进行了系统的电子研究。介绍在LLND期间使用ICG的研究，特别是在收集的淋巴结方面，包括在内并进行了审查。比较LLND与ICG(LLND+ICG)或无ICG(LLND-单独)的研究进一步分析淋巴结数目和术后结果。
结果：总计，发现13项研究合格，并分析了不同的参数。LLND+ICG与收集的外侧淋巴结数量显着增加有关（p<0.05），轻微失血,减少手术时间，与单用LLND相比，术后尿潴留可能减少。
结论：在LLND期间使用ICG荧光是平衡术后结果和收集的淋巴结数量的安全可行的技术。需要精心设计的具有长期结果的研究来阐明肿瘤学益处并建立这种有前途的技术。
