METHODS: Systematic electronic research was conducted in PubMed and Google Scholar using a combination of medical subject headings (MeSH). Studies presenting the use of ICG during LLND, especially in terms of harvested lymph nodes, were included and reviewed. Studies comparing LLND with ICG (LLND + ICG) or without ICG (LLND-alone) were further analyzed for the number of lymph nodes and postoperative outcomes.
RESULTS: In total, 13 studies were found eligible and analyzed for different parameters. LLND + ICG is associated with significantly increased number of harvested lateral lymph nodes (p < 0.05), minor blood loss, decreased operative time, and probably decreased urinary retention postoperatively compared with LLND-alone.
CONCLUSIONS: The use of ICG fluorescence during LLND is a safe and feasible technique for balancing postoperative outcomes and the number of harvested lymph nodes. Well-designed studies with long-term results are required to elucidate the oncological benefits and establish this promising technique.
方法:在PubMed和GoogleScholar中使用医学主题词(MeSH)的组合进行了系统的电子研究。介绍在LLND期间使用ICG的研究,特别是在收集的淋巴结方面,包括在内并进行了审查。比较LLND与ICG(LLND+ICG)或无ICG(LLND-单独)的研究进一步分析淋巴结数目和术后结果。
结果:总计,发现13项研究合格,并分析了不同的参数。LLND+ICG与收集的外侧淋巴结数量显着增加有关(p<0.05),轻微失血,减少手术时间,与单用LLND相比,术后尿潴留可能减少。
结论:在LLND期间使用ICG荧光是平衡术后结果和收集的淋巴结数量的安全可行的技术。需要精心设计的具有长期结果的研究来阐明肿瘤学益处并建立这种有前途的技术。