PDF(Pubmed)
Abstract：
Early research suggested that bone morphogenetic protein 10 (BMP10) is primarily involved in cardiac development and congenital heart disease processes. BMP10 is a newly identified cardiac-specific protein. In recent years, reports have emphasized the effects of BMP10 on myocardial apoptosis, fibrosis and immune response, as well as its synergistic effects with BMP9 in vascular endothelium and role in endothelial dysfunction. We believe that concentrating on this aspect of the study will enhance our knowledge of the pathogenesis of diabetes and the cardiovascular field. However, there have been no reports of any reviews discussing the role of BMP10 in diabetes and cardiovascular disease. In addition, the exact pathogenesis of diabetic cardiomyopathy is not fully understood, including myocardial energy metabolism disorders, microvascular changes, abnormal apoptosis of cardiomyocytes, collagen structural changes and myocardial fibrosis, all of which cause cardiac function impairment directly or indirectly and interact with one another. This review summarizes the research results of BMP10 in cardiac development, endothelial function and cardiovascular disease in an effort to generate new ideas for future research into diabetic cardiomyopathy.
摘要：
早期研究表明，骨形态发生蛋白10（BMP10）主要参与心脏发育和先天性心脏病过程。BMP10是一种新鉴定的心脏特异性蛋白。近年来,有报道强调了BMP10对心肌细胞凋亡的影响，纤维化和免疫反应，以及它与BMP9在血管内皮中的协同作用和在内皮功能障碍中的作用。我们相信，专注于这方面的研究将提高我们对糖尿病和心血管领域的发病机理的认识。然而,目前尚无关于BMP10在糖尿病和心血管疾病中的作用的综述报道.此外,糖尿病性心肌病的确切发病机制尚不完全清楚,包括心肌能量代谢紊乱,微血管改变,心肌细胞异常凋亡，胶原结构改变和心肌纤维化,所有这些都直接或间接地导致心脏功能损害，并相互作用。本文就BMP10在心脏发育中的研究进展作一综述。血管内皮功能和心血管疾病，为未来糖尿病心肌病的研究提供新的思路。
