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Abstract：
BACKGROUND: Polypharmacy would increase the risk of adverse drug events and the burden of renal drug excretion among older people. Nevertheless, the association between the number of medication and the risk of chronic kidney disease (CKD) remains controversial. Therefore, this study aims to investigate the association between the number of medication and the incidence of CKD in older people.
METHODS: This study investigates the association between the number of medications and CKD in 2672 elderly people (≥ 65 years older) of the community health service center in southern China between 2019 and 2022. Logistic regression analysis was used to evaluate the relationship between polypharmacy and CKD.
RESULTS: At baseline, the average age of the study subjects was 71.86 ± 4.60, 61.2% were females, and 53 (2.0%) suffer from polypharmacy. During an average follow-up of 3 years, new-onset CKD developed in 413 (15.5%) participants. Logistic regression analysis revealed that taking a higher number of medications was associated with increase of CKD. Compared with people who didn\'t take medication, a higher risk of CKD was observed in the older people who taken more than five medications (OR 3.731, 95% CI 1.988, 7.003), followed by those who take four (OR 1.621, 95% CI 1.041, 2.525), three (OR 1.696, 95% CI 1.178, 2.441), two drugs (OR 1.585, 95% CI 1.167, 2.153), or one drug (OR 1.503, 95% CI 1.097, 2.053). Furthermore, age, systolic blood pressure (SBP), white blood cell (WBC), blood urea nitrogen (BUN) and triglyceride (TG) were also independent risk factors CKD (P < 0.05).
CONCLUSIONS: The number of medications was associated with CKD in older people. As the number of medications taken increased, the risk of CKD was increased.
METHODS: This study investigates the association between the number of medications and CKD in 2672 elderly people (≥ 65 years older) of the community health service center in southern China between 2019 and 2022. Logistic regression analysis was used to evaluate the relationship between polypharmacy and CKD.
RESULTS: At baseline, the average age of the study subjects was 71.86 ± 4.60, 61.2% were females, and 53 (2.0%) suffer from polypharmacy. During an average follow-up of 3 years, new-onset CKD developed in 413 (15.5%) participants. Logistic regression analysis revealed that taking a higher number of medications was associated with increase of CKD. Compared with people who didn\'t take medication, a higher risk of CKD was observed in the older people who taken more than five medications (OR 3.731, 95% CI 1.988, 7.003), followed by those who take four (OR 1.621, 95% CI 1.041, 2.525), three (OR 1.696, 95% CI 1.178, 2.441), two drugs (OR 1.585, 95% CI 1.167, 2.153), or one drug (OR 1.503, 95% CI 1.097, 2.053). Furthermore, age, systolic blood pressure (SBP), white blood cell (WBC), blood urea nitrogen (BUN) and triglyceride (TG) were also independent risk factors CKD (P < 0.05).
CONCLUSIONS: The number of medications was associated with CKD in older people. As the number of medications taken increased, the risk of CKD was increased.
摘要：
背景：多重用药会增加老年人发生不良药物事件的风险和肾脏药物排泄的负担。然而，用药数量与慢性肾脏病(CKD)风险之间的关联仍存在争议.因此,本研究旨在探讨老年人中药物治疗数量与CKD发病率之间的关系.
方法：本研究调查了2019年至2022年中国南方社区卫生服务中心2672名老年人（≥65岁）的用药数量与CKD的关系。采用Logistic回归分析评价多重用药与CKD的关系。
结果：在基线时，研究对象的平均年龄为71.86±4.60，61.2%为女性，53人(2.0%)患有多重用药。平均随访3年,413名(15.5%)参与者出现新发CKD.Logistic回归分析显示，服用较多药物与CKD的增加有关。与不服药的人相比，服用5种以上药物的老年人患CKD的风险较高(OR3.731,95%CI1.988,7.003),其次是服用四次的人(OR1.621，95%CI1.041，2.525)，三（OR1.696，95%CI1.178，2.441），两种药物（OR1.585，95%CI1.167，2.153），或一种药物（OR1.503，95%CI1.097，2.053）。此外，年龄,收缩压（SBP），白细胞（WBC），尿素氮(BUN)和甘油三酯(TG)也是CKD的独立危险因素(P<0.05)。
结论：老年患者的用药数量与CKD相关。随着服用药物数量的增加，CKD的风险增加.
方法：本研究调查了2019年至2022年中国南方社区卫生服务中心2672名老年人（≥65岁）的用药数量与CKD的关系。采用Logistic回归分析评价多重用药与CKD的关系。
结果：在基线时，研究对象的平均年龄为71.86±4.60，61.2%为女性，53人(2.0%)患有多重用药。平均随访3年,413名(15.5%)参与者出现新发CKD.Logistic回归分析显示，服用较多药物与CKD的增加有关。与不服药的人相比，服用5种以上药物的老年人患CKD的风险较高(OR3.731,95%CI1.988,7.003),其次是服用四次的人(OR1.621，95%CI1.041，2.525)，三（OR1.696，95%CI1.178，2.441），两种药物（OR1.585，95%CI1.167，2.153），或一种药物（OR1.503，95%CI1.097，2.053）。此外，年龄,收缩压（SBP），白细胞（WBC），尿素氮(BUN)和甘油三酯(TG)也是CKD的独立危险因素(P<0.05)。
结论：老年患者的用药数量与CKD相关。随着服用药物数量的增加，CKD的风险增加.
