PDF(Pubmed)
Abstract：
BACKGROUND: Numerous researches have indicated a correlation between the intake of dietary micronutrients and the occurrence of constipation. Nevertheless, the correlation between constipation and vitamin B1 remains uninvestigated. The main aim of this research was to examine the association between chronic constipation and the consumption of vitamin B1 in the diet among adult participants of the National Health and Nutrition Examination Survey (NHANES).
METHODS: This study used data from the NHANES, a survey on health and nutrition conducted between 2005 and 2010. The respondents\' dietary information was gathered by utilizing the 24-hour dietary records. Various statistical analyses, such as multiple logistic regression, subgroup analysis, and curve-fitting analysis, were employed to investigate the correlation between dietary intake of vitamin B1 and chronic constipation.
RESULTS: In the trial, there were 10,371 participants, out of which 1,123 individuals (10.8%) were identified as having chronic constipation. Fully adjusted multiple logistic regression analyses showed that increasing dietary intake of vitamin B1 (OR = 0.87, 95% CI: 0.77-0.99) was significantly associated with a reduced risk of constipation. Following adjustment for multiple variables in Model 3, the odds ratio (OR) and 95% confidence interval (CI) for the third tertile, in comparison to the first tertile (reference group), was 0.80 (0.65, 0.99). In addition, subgroup analyses and interaction tests showed a significant inverse association between vitamin B1 intake and the prevalence of constipation, especially among men, non-hypertensive, and non-diabetic individuals (all P-values less than 0.05).
CONCLUSIONS: This research uncovered an inverse correlation between the consumption of vitamin B1 in the diet and the occurrence of chronic constipation. One potential explanation for this phenomenon is that the consumption of vitamin B1 in one\'s diet is linked to the softening of stools and an augmented occurrence of colonic peristalsis. Additional extensive prospective research is required to thoroughly examine the significance of thiamine in long-term constipation.
METHODS: This study used data from the NHANES, a survey on health and nutrition conducted between 2005 and 2010. The respondents\' dietary information was gathered by utilizing the 24-hour dietary records. Various statistical analyses, such as multiple logistic regression, subgroup analysis, and curve-fitting analysis, were employed to investigate the correlation between dietary intake of vitamin B1 and chronic constipation.
RESULTS: In the trial, there were 10,371 participants, out of which 1,123 individuals (10.8%) were identified as having chronic constipation. Fully adjusted multiple logistic regression analyses showed that increasing dietary intake of vitamin B1 (OR = 0.87, 95% CI: 0.77-0.99) was significantly associated with a reduced risk of constipation. Following adjustment for multiple variables in Model 3, the odds ratio (OR) and 95% confidence interval (CI) for the third tertile, in comparison to the first tertile (reference group), was 0.80 (0.65, 0.99). In addition, subgroup analyses and interaction tests showed a significant inverse association between vitamin B1 intake and the prevalence of constipation, especially among men, non-hypertensive, and non-diabetic individuals (all P-values less than 0.05).
CONCLUSIONS: This research uncovered an inverse correlation between the consumption of vitamin B1 in the diet and the occurrence of chronic constipation. One potential explanation for this phenomenon is that the consumption of vitamin B1 in one\'s diet is linked to the softening of stools and an augmented occurrence of colonic peristalsis. Additional extensive prospective research is required to thoroughly examine the significance of thiamine in long-term constipation.
摘要：
背景：大量研究表明膳食微量营养素的摄入与便秘的发生之间存在相关性。然而，便秘与维生素B1之间的相关性仍未研究。这项研究的主要目的是研究国家健康与营养检查调查（NHANES）的成年参与者中慢性便秘与饮食中维生素B1消耗之间的关系。
方法：这项研究使用了来自NHANES的数据，2005年至2010年进行的健康和营养调查。受访者的饮食信息是通过利用24小时饮食记录收集的。各种统计分析，如多元逻辑回归，亚组分析，和曲线拟合分析，研究了膳食摄入维生素B1与慢性便秘的相关性。
结果：在试验中，有10371名参与者,其中1,123人（10.8%）被确定为患有慢性便秘。完全调整的多元logistic回归分析显示，增加维生素B1的饮食摄入量（OR=0.87，95％CI：0.77-0.99）与便秘风险降低显着相关。在对模型3中的多个变量进行调整后，第三个三分位数的比值比(OR)和95%置信区间(CI)，与第一个三分位数(参照组)相比，为0.80（0.65，0.99）。此外,亚组分析和交互作用测试显示，维生素B1摄入量与便秘患病率之间存在显著的负相关，尤其是在男性中,非高血压,和非糖尿病个体（所有P值小于0.05）。
结论：这项研究揭示了饮食中维生素B1的消耗与慢性便秘的发生之间的负相关。这种现象的一个潜在解释是，饮食中维生素B1的消耗与大便软化和结肠蠕动增加有关。需要进行更广泛的前瞻性研究，以彻底检查硫胺素在长期便秘中的重要性。
方法：这项研究使用了来自NHANES的数据，2005年至2010年进行的健康和营养调查。受访者的饮食信息是通过利用24小时饮食记录收集的。各种统计分析，如多元逻辑回归，亚组分析，和曲线拟合分析，研究了膳食摄入维生素B1与慢性便秘的相关性。
结果：在试验中，有10371名参与者,其中1,123人（10.8%）被确定为患有慢性便秘。完全调整的多元logistic回归分析显示，增加维生素B1的饮食摄入量（OR=0.87，95％CI：0.77-0.99）与便秘风险降低显着相关。在对模型3中的多个变量进行调整后，第三个三分位数的比值比(OR)和95%置信区间(CI)，与第一个三分位数(参照组)相比，为0.80（0.65，0.99）。此外,亚组分析和交互作用测试显示，维生素B1摄入量与便秘患病率之间存在显著的负相关，尤其是在男性中,非高血压,和非糖尿病个体（所有P值小于0.05）。
结论：这项研究揭示了饮食中维生素B1的消耗与慢性便秘的发生之间的负相关。这种现象的一个潜在解释是，饮食中维生素B1的消耗与大便软化和结肠蠕动增加有关。需要进行更广泛的前瞻性研究，以彻底检查硫胺素在长期便秘中的重要性。
