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Abstract：
Oxalate, a uremic toxin that accumulates in dialysis patients, is associated with cardiovascular disease. As oxalate crystals can activate immune cells, we tested the hypothesis that plasma oxalate would be associated with cytokine concentrations and cardiovascular outcomes in dialysis patients. In a cohort of 104 US patients with kidney failure requiring dialysis (cohort 1), we measured 21 inflammatory markers. As IL-16 was the only cytokine to correlate with oxalate, we focused further investigations on IL-16. We searched for associations between concentrations of IL-16 and mortality and cardiovascular events in the 4D cohort (1255 patients, cohort 2) and assessed further associations of IL-16 with other uremic toxins in this cohort. IL-16 levels were positively correlated with pOx concentrations (ρ = 0.39 in cohort 1, r = 0.35 in cohort 2) and were elevated in dialysis patients when compared to healthy individuals. No significant association could be found between IL-16 levels and cardiovascular events or mortality in the 4D cohort. We conclude that the cytokine IL-16 correlates with plasma oxalate concentrations and is substantially increased in patients with kidney failure on dialysis. However, no association could be detected between IL-16 concentrations and cardiovascular disease in the 4D cohort.
摘要：
草酸盐,积累在透析患者体内的尿毒症毒素，与心血管疾病相关。草酸盐晶体可以激活免疫细胞，我们检验了透析患者血浆草酸盐与细胞因子浓度和心血管结局相关的假设.在104名需要透析的肾衰竭美国患者的队列中（队列1），我们测量了21种炎症标志物。由于IL-16是唯一与草酸盐相关的细胞因子，我们的研究重点是IL-16.我们在4D队列中搜索了IL-16浓度与死亡率和心血管事件之间的关联（1255例患者，队列2），并评估了该队列中IL-16与其他尿毒症毒素的进一步关联。IL-16水平与pOx浓度呈正相关（队列1中ρ=0.39，队列2中r=0.35），与健康个体相比，透析患者的IL-16水平升高。在4D队列中，IL-16水平与心血管事件或死亡率之间没有发现显着关联。我们得出的结论是，细胞因子IL-16与血浆草酸盐浓度相关，并且在透析的肾衰竭患者中大大增加。然而,在4D队列中未检测到IL-16浓度与心血管疾病之间的关联.
