Abstract：
In the vast landscape of human health, head and neck cancer (HNC) poses a significant health burden globally, necessitating the exploration of novel diagnostics and therapeutics. Metabolic alterations occurring within tumor microenvironment are crucial to understand the foundational cause of HNC. Post-translational modifications (PTMs) have recently emerged as a silent foe exerting a significantly heightened influence on various aspects of the biological processes associated with the onset and advancement of cancer, particularly in the context of HNC. There are numerous targets involved in HNC but recently, the enzyme pyruvate kinase M2 (PKM2) has come out as a hot target due to its involvement in glycolysis resulting in metabolic reprogramming of cancer cells. Various PTMs have been reported to affect the structure and function of PKM2 by modulating its activity. This review aims to investigate the impact of PTMs on the interaction between PKM2 and several signaling pathways and transcription factors in the context of HNC. These interactions possess significant ramification for cellular proliferation, apoptosis, angiogenesis and metastasis. This review primarily explores the role of PTMs influencing PKM2 and its involvement in tumor development. While acknowledging the significance of PKM2 interactions with other tumor regulators, the emphasis lies on dissecting PTM-related mechanisms rather than solely scrutinizing individual regulators. It lays the framework for the development of more sophisticated diagnostic tools and uncovers exciting possibilities for precision medicine essential for effectively addressing the complexity of this malignancy in a precise and focused manner.
摘要：
在人类健康的广阔景观中，头颈癌（HNC）在全球范围内构成了巨大的健康负担，需要探索新的诊断和治疗方法。肿瘤微环境中发生的代谢改变对于理解HNC的根本原因至关重要。翻译后修饰（PTM）最近已成为沉默的敌人，对与癌症发作和发展相关的生物过程的各个方面产生了显着增强的影响。特别是在HNC的背景下。HNC涉及许多目标，但最近，丙酮酸激酶M2(PKM2)由于其参与导致癌细胞代谢重编程的糖酵解而成为热门靶标。已经报道了各种PTM通过调节PKM2的活性来影响其结构和功能。本文旨在探讨HNC背景下PTMs对PKM2与多种信号通路和转录因子相互作用的影响。这些相互作用对细胞增殖具有显著的影响，凋亡，血管生成和转移。本文主要探讨PTMs对PKM2的影响及其在肿瘤发生发展中的作用。虽然承认PKM2与其他肿瘤调节因子相互作用的重要性，重点在于剖析与PTM相关的机制，而不是仅仅审查单个监管机构。它为开发更复杂的诊断工具奠定了框架，并揭示了精确医学的令人兴奋的可能性，这对于以精确和集中的方式有效解决这种恶性肿瘤的复杂性至关重要。
