Abstract：
Bedrest as an experimental paradigm or as an in-patient stay for medical reasons has negative consequences for cardiovascular health. The effects of severe inactivity parallel many of the changes experienced with natural aging but over a much shorter duration. Cardiac function is reduced, arteries stiffen, neural reflex responses are impaired, and metabolic and oxidative stress responses impose burden on the heart and vascular systems. The effect of these changes is revealed in studies of integrative function. Aerobic fitness progressively deteriorates with bedrest and tolerance of upright posture is rapidly impaired. In this review we consider the similarities of aging and bedrest-induced cardiovascular deconditioning. We concur with many recent clinical recommendations that early and regular mobility with upright posture will reduce likelihood of hospital-associated disability related to bedrest.
摘要：
床前休息作为实验范例或由于医疗原因而住院对心血管健康具有负面影响。严重不活动的影响与自然衰老所经历的许多变化平行，但持续时间短得多。心功能下降,动脉硬化,神经反射反应受损，代谢和氧化应激反应给心脏和血管系统带来负担。在整合功能的研究中揭示了这些变化的影响。卧床休息会使有氧健身逐渐恶化，直立姿势的耐受性迅速受损。这篇综述考虑了衰老与卧床诱发的心血管疾病之间的相似性。我们同意许多最近的临床建议，即直立姿势的早期和定期活动将减少与卧床有关的医院相关残疾的可能性。
