整合的分子和空间分析揭示了原位和侵袭性肢端黑色素瘤的进化动力学和肿瘤免疫相互作用。
关键词: APOE CD163 acral melanoma genomic instability intratumor heterogeneity molecular subtype spatial omics tumor evolution tumor-associated macrophage
Mesh : Humans Melanoma / genetics immunology pathology Epithelial-Mesenchymal Transition / genetics Skin Neoplasms / genetics immunology pathology Antigens, Differentiation, Myelomonocytic / metabolism genetics Antigens, CD / metabolism genetics Neoplasm Invasiveness Apolipoproteins E / genetics Macrophages / immunology metabolism Male Female Receptor, IGF Type 1 / genetics metabolism Tumor Microenvironment / immunology genetics Biomarkers, Tumor / genetics metabolism Gene Expression Regulation, Neoplastic Spatial Analysis Middle Aged Prognosis Disease Progression Aged Receptors, Cell Surface
来 源: DOI:10.1016/j.ccell.2024.04.012