揭示铁凋亡中的 ETC 复合物 I 功能揭示了 LKB1 缺陷型癌症的潜在铁凋亡诱导治疗策略。
关键词: AMPK ETC complex I LKB1 cancer therapy ferroptosis lipid peroxidation mitochondria
Mesh : Animals Female Humans Mice AMP-Activated Protein Kinase Kinases / genetics AMP-Activated Protein Kinases / metabolism genetics Cell Line, Tumor Electron Transport Complex I / metabolism genetics Ferroptosis / genetics drug effects Mitochondria / metabolism genetics drug effects Neoplasms / genetics pathology metabolism drug therapy Phospholipid Hydroperoxide Glutathione Peroxidase / metabolism genetics Protein Serine-Threonine Kinases / metabolism genetics Signal Transduction Xenograft Model Antitumor Assays
来 源:
DOI:10.1016/j.molcel.2024.04.009
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