Abstract：
Despite their relatively short lifespan, neutrophils are tasked with counteracting pathogens through various functions, including phagocytosis, production of reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and host defence peptides. Regarding the latter, small cationic cathelicidins present a conundrum in neutrophil function. Although primarily recognized as microbicides with an ability to provoke pores in microbial cell walls, the ability of cathelicidin to modulate key neutrophil functions is also of great importance, including the release of chemo-attractants, cytokines and ROS, plus prolonging neutrophil lifespan. Cumulative evidence indicates a less recognized role of cathelicidin as an \"immunomodulator;\" however, this term is not always explicit and its relevance in neutrophil responses during infection and inflammation is seldom discussed. This review compiles and discusses studies of how neutrophils use cathelicidin to respond to infections, while also acknowledging immunomodulatory aspects of cathelicidin through potential crosstalk between sources of the peptide.
摘要：
尽管它们的寿命相对较短，中性粒细胞的任务是通过各种功能对抗病原体，包括吞噬作用,活性氧（ROS）的产生，中性粒细胞胞外陷阱（NET），和宿主防御肽。关于后者,小阳离子阴极素在中性粒细胞功能中存在一个难题。尽管主要被认为是具有激发微生物细胞壁中的孔的能力的杀微生物剂，cathelicidin调节关键中性粒细胞功能的能力也非常重要，包括化学引诱剂的释放，细胞因子和ROS，再加上延长中性粒细胞寿命.累积证据表明，导管素作为“免疫调节剂”的作用较少；然而，该术语并不总是明确的,其与感染和炎症期间中性粒细胞反应的相关性很少被讨论.这篇综述汇编并讨论了嗜中性粒细胞如何使用cathelicidin对感染做出反应的研究，同时还通过肽来源之间的潜在串扰确认了导管素的免疫调节方面。
