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Abstract：
Human immunodeficiency virus (HIV) infection continues to pose significant global health challenges, necessitating advancements in diagnostic and prognostic approaches to optimize disease management. While primarily recognized for their roles in allergic responses, mast cells have emerged as potential markers with diagnostic and prognostic significance in the context of HIV/AIDS. This paper aims to synthesize current insights and delineate future directions regarding the utility of mast cell markers in diagnosing HIV infection, predicting disease progression, and guiding therapeutic strategies. Mast cells, equipped with distinct markers such as tryptase, chymase, carboxypeptidase A3, and c-kit/CD117 receptors, exhibit tissue-specific expression patterns that offer potential as diagnostic indicators for HIV infection. Understanding the dynamics of these markers in different tissues and body fluids holds promise for accurate HIV diagnosis, disease staging, and monitoring treatment responses. Moreover, the prognostic significance of mast cell markers in HIV/AIDS lies in their potential to predict disease progression, immune dysregulation, and clinical outcomes. The integration of mast cell markers into clinical applications offers promising avenues for refining diagnostic assays, patient monitoring protocols, and therapeutic strategies in HIV/AIDS. Future research directions involve the development of novel diagnostic tools and targeted therapies based on mast cell-specific markers, potentially revolutionizing clinical practice and enhancing patient care in the management of HIV/AIDS. Continued investigations into mast cell markers\' diagnostic and prognostic implications hold immense potential to advance our understanding and improve outcomes in HIV/AIDS management.
摘要：
人类免疫缺陷病毒(HIV)感染继续构成重大的全球卫生挑战,需要改进诊断和预后方法以优化疾病管理。虽然主要认识到它们在过敏反应中的作用，肥大细胞已成为HIV/AIDS背景下具有诊断和预后意义的潜在标志物。本文旨在综合当前的见解，并描述肥大细胞标志物在诊断HIV感染中的实用性的未来方向。预测疾病进展，指导治疗策略。肥大细胞,配备不同的标记，如胰蛋白酶，糜蛋白酶,羧肽酶A3和c-kit/CD117受体，表现出组织特异性表达模式，可作为HIV感染的诊断指标。了解这些标志物在不同组织和体液中的动态为准确的HIV诊断提供了希望。疾病分期,并监测治疗反应。此外，肥大细胞标志物在HIV/AIDS中的预后意义在于其预测疾病进展的潜力，免疫失调，和临床结果。将肥大细胞标记物整合到临床应用中，为完善诊断分析提供了有希望的途径。病人监护协议,和艾滋病毒/艾滋病的治疗策略。未来的研究方向包括开发新的诊断工具和基于肥大细胞特异性标志物的靶向治疗。在艾滋病毒/艾滋病的管理中，有可能彻底改变临床实践并加强患者护理。对肥大细胞标志物的诊断和预后影响的持续调查具有巨大的潜力，可以增进我们的理解并改善HIV/AIDS管理的结果。
