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Abstract：
BACKGROUND: This randomized controlled trial aimed to evaluate the efficacy of preoperative inhaled budesonide combined with intravenous dexamethasone on postoperative sore throat (POST) after general anesthesia in patients who underwent thyroidectomy.
METHODS: Patients who underwent elective thyroidectomy were randomly divided into the intravenous dexamethasone group (group A) and budesonide inhalation combined with intravenous dexamethasone group (group B). All patients underwent general anesthesia. The incidence and severity of POST, hoarseness, and cough at 1, 6, 12, and 24 hours after surgery were evaluated and compared between the 2 groups.
RESULTS: There were 48 and 49 patients in groups A and B, respectively. The incidence of POST was significantly lower at 6, 12, and 24 hours in group B than that in group A (P < .05). In addition, group B had a significantly lower incidence of coughing at 24 hours (P = .047). Compared with group A, the severity of POST was significantly lower at 6 (P = .027), 12 (P = .004), and 24 (P = .005) hours at rest, and at 6 (P = .002), 12 (P = .038), and 24 (P = .015) hours during swallowing in group B. The incidence and severity of hoarseness were comparable at each time-point between the 2 groups (P > .05).
CONCLUSIONS: Preoperative inhaled budesonide combined with intravenous dexamethasone reduced the incidence and severity of POST at 6, 12, and 24 hours after extubation compared with intravenous dexamethasone alone in patients who underwent thyroidectomy. Additionally, this combination decreased the incidence of postoperative coughing at 24 hours.
METHODS: Patients who underwent elective thyroidectomy were randomly divided into the intravenous dexamethasone group (group A) and budesonide inhalation combined with intravenous dexamethasone group (group B). All patients underwent general anesthesia. The incidence and severity of POST, hoarseness, and cough at 1, 6, 12, and 24 hours after surgery were evaluated and compared between the 2 groups.
RESULTS: There were 48 and 49 patients in groups A and B, respectively. The incidence of POST was significantly lower at 6, 12, and 24 hours in group B than that in group A (P < .05). In addition, group B had a significantly lower incidence of coughing at 24 hours (P = .047). Compared with group A, the severity of POST was significantly lower at 6 (P = .027), 12 (P = .004), and 24 (P = .005) hours at rest, and at 6 (P = .002), 12 (P = .038), and 24 (P = .015) hours during swallowing in group B. The incidence and severity of hoarseness were comparable at each time-point between the 2 groups (P > .05).
CONCLUSIONS: Preoperative inhaled budesonide combined with intravenous dexamethasone reduced the incidence and severity of POST at 6, 12, and 24 hours after extubation compared with intravenous dexamethasone alone in patients who underwent thyroidectomy. Additionally, this combination decreased the incidence of postoperative coughing at 24 hours.
摘要：
背景：这项随机对照试验旨在评估术前吸入布地奈德联合静脉注射地塞米松对甲状腺切除术患者全麻术后咽喉痛（POST）的疗效。
方法：择期甲状腺切除术患者随机分为静脉注射地塞米松组(A组)和雾化吸入布地奈德联合静脉注射地塞米松组(B组)。所有患者均行全身麻醉。POST的发生率和严重程度，声音嘶哑,术后1、6、12和24小时咳嗽进行评价和比较。
结果：A组和B组分别有48和49例患者，分别。B组术后6、12、24hPOST发生率明显低于A组(P<0.05)。此外,B组24小时咳嗽的发生率明显降低（P=0.047）。与A组相比,POST的严重程度在6时显著降低(P=.027)，12(P=.004)，休息24小时（P=0.005），在6（P=0.002），12（P=.038），B组吞咽过程中24小时（P=0.015）。两组之间在每个时间点的声音嘶哑的发生率和严重程度具有可比性（P>.05）。
结论：术前吸入布地奈德联合静脉注射地塞米松可降低甲状腺切除术患者拔管后6、12和24小时POST的发生率和严重程度。此外,这种组合降低了术后24小时咳嗽的发生率.
方法：择期甲状腺切除术患者随机分为静脉注射地塞米松组(A组)和雾化吸入布地奈德联合静脉注射地塞米松组(B组)。所有患者均行全身麻醉。POST的发生率和严重程度，声音嘶哑,术后1、6、12和24小时咳嗽进行评价和比较。
结果：A组和B组分别有48和49例患者，分别。B组术后6、12、24hPOST发生率明显低于A组(P<0.05)。此外,B组24小时咳嗽的发生率明显降低（P=0.047）。与A组相比,POST的严重程度在6时显著降低(P=.027)，12(P=.004)，休息24小时（P=0.005），在6（P=0.002），12（P=.038），B组吞咽过程中24小时（P=0.015）。两组之间在每个时间点的声音嘶哑的发生率和严重程度具有可比性（P>.05）。
结论：术前吸入布地奈德联合静脉注射地塞米松可降低甲状腺切除术患者拔管后6、12和24小时POST的发生率和严重程度。此外,这种组合降低了术后24小时咳嗽的发生率.
