Abstract：
Rheumatoid arthritis (RA) is a systemic immune disease with severe implications for joint health. The issue of non-specific drug distribution potentially limits the therapeutic efficacy and increases the risk associated with RA treatment. Researchers employed cytomembrane-coated biomimetic nanoparticles (NPs) to enhance the targeting delivery efficacy to meet the demand for drug accumulation within the affected joints. Furthermore, distinct cytomembranes offer unique functionalities, such as immune cell activation and augmented NP biocompatibility. In this review, the current strategies of RA treatments were summarized in detail, and then an overview of RA\'s pathogenesis and the methodologies for producing cytomembrane-coated biomimetic NPs was provided. The application of cytomembrane biomimetic NPs derived from various cell sources in RA therapy is explored, highlighting the distinctive attributes of individual cytomembranes as well as hybrid membrane configurations. Through this comprehensive assessment of cytomembrane biomimetic NPs, we elucidate the prospective applications and challenges in the realm of RA therapy, and the strategy of combined therapy is proposed. In the future, cytomembrane biomimetic NPs have a broad therapeutic prospect for RA.
摘要：
类风湿性关节炎（RA）是一种全身性免疫疾病，对关节健康具有严重影响。非特异性药物分布的问题潜在地限制了治疗功效并增加了与RA治疗相关的风险。研究人员采用细胞膜包被的仿生纳米颗粒（NPs）来增强靶向递送功效，以满足受影响关节内药物积累的需求。此外，不同的细胞膜提供独特的功能，如免疫细胞活化和增强NP生物相容性。在这次审查中,详细总结了当前的RA治疗策略，然后概述了RA的发病机理和产生细胞膜涂层仿生NPs的方法。探索各种细胞来源的细胞膜仿生NPs在RA治疗中的应用。突出了单个细胞膜的独特属性以及杂化膜构型。通过对细胞膜仿生NPs的全面评估，我们阐明了RA治疗领域的未来应用和挑战，并提出了综合治疗的策略。在未来,细胞膜仿生NPs对RA具有广阔的治疗前景。
