PDF(Pubmed)
Abstract：
Since its discovery in 1965, our understanding of the hepatitis B virus (HBV) replication cycle and host immune responses has increased markedly. In contrast, our knowledge of the molecular biology of hepatitis delta virus (HDV), which is associated with more severe liver disease, is less well understood. Despite the progress made, critical gaps remain in our knowledge of HBV and HDV replication and the mechanisms underlying viral persistence and evasion of host immunity. The International HBV Meeting is the leading annual scientific meeting for presenting the latest advances in HBV and HDV molecular virology, immunology, and epidemiology. In 2023, the annual scientific meeting was held in Kobe, Japan and this review summarises some of the advances presented at the Meeting and lists gaps in our knowledge that may facilitate the development of new therapies.
摘要：
自1965年发现以来，我们对乙型肝炎病毒（HBV）复制周期和宿主免疫反应的理解显着增加。相比之下,我们对丁型肝炎病毒（HDV）分子生物学的了解，这与更严重的肝脏疾病相关，不太了解。尽管取得了进展,我们对HBV和HDV复制的知识以及病毒持续存在和逃避宿主免疫的机制仍然存在关键差距。国际HBV会议是介绍HBV和HDV分子病毒学的最新进展的领先年度科学会议，免疫学,和流行病学。2023年，年度科学会议在神户举行，日本和本审查总结了会议上提出的一些进展，并列出了我们知识中可能有助于开发新疗法的差距。
