Abstract：
Obstructive sleep apnea (OSA) is a chronic inflammatory disease characterized by partial or complete upper airway obstruction during sleep. We aimed to evaluate serum/plasma levels of several cytokines (interleukin [IL]-6, IL-12, IL-17, IL-18, and IL-23) in a systematic review meta-analysis in both adults and children with OSA compared with controls. We conducted a comprehensive search of 4 digital databases (PubMed, Web of Science, Scopus, and Cochrane Library) up until October 19, 2023, without any limitations. For our meta-analysis, we used Review Manager, version 5.3, and displayed the data as the standardized mean difference (SMD) and 95% confidence interval (CI) to assess the correlation between cytokine levels and OSA. We utilized Comprehensive Meta-Analysis version 3.0 software to conduct bias analyses, meta-regression, and sensitivity analyses. From 1881 records, 84 articles were included in the systematic review and meta-analysis. In adults, the pooled SMDs for IL-6 level were 0.79 (P value < 0.00001), for IL-17 level were 0.74 (P value = 0.14), and for IL-18 level were 0.43 (P value = 0.00002). In children, the pooled SMD for IL-6 was 1.10 (P value < 0.00001), for IL-12 was 0.47 (P value = 0.10), for IL-17 was 2.21 (a P value = 0.24), for IL-18 was 0.19 (P value = 0.07), and for IL-23 was 2.46 (P value < 0.0001). The subgroup analysis showed that the ethnicity, mean body mass index, and mean apnea-hypopnea index for IL-6 levels in adults and the ethnicity for IL-6 levels in children were effective factors in the pooled SMD. The findings of the trial sequential analysis revealed that adequate evidence has been obtained. The analysis of IL levels in adults and children with OSA compared with those without OSA revealed significant differences. In adults, IL-6 and IL-18 levels were significantly higher in the OSA group, while in children, only IL-6 and IL-23 levels were significantly elevated.
摘要：
阻塞性睡眠呼吸暂停（OSA）是一种慢性炎症性疾病，其特征是睡眠期间部分或完全上呼吸道阻塞。我们的目的是评估血清/血浆中的几种细胞因子（白细胞介素[IL]-6，IL-12，IL-17，IL-18和IL-23）在成人和儿童OSA与对照组相比的系统评价荟萃分析。我们对4个数字数据库(PubMed，WebofScience,Scopus,和Cochrane图书馆)，直到2023年10月19日，没有任何限制。对于我们的荟萃分析，我们使用了ReviewManager,5.3版，并将数据显示为标准化平均差（SMD）和95％置信区间（CI），以评估细胞因子水平与OSA之间的相关性。我们利用综合荟萃分析3.0版软件进行偏倚分析，元回归，和敏感性分析。根据1881年的记录，84篇文献纳入系统评价和荟萃分析。在成年人中,IL-6水平的合并SMD为0.79（P值<0.00001），IL-17水平为0.74（P值=0.14），IL-18水平为0.43（P值=0.00002）。在儿童中，IL-6的合并SMD为1.10（P值<0.00001），IL-12为0.47（P值=0.10），IL-17为2.21（P值=0.24），IL-18为0.19（P值=0.07），IL-23为2.46（P值<0.0001）。亚组分析表明，种族，平均体重指数，成人IL-6水平的平均呼吸暂停低通气指数和儿童IL-6水平的种族是合并SMD的有效因素。试验序贯分析的结果表明，已经获得了足够的证据。与没有OSA的成人和儿童相比，患有OSA的成人和儿童的IL水平分析显示出显着差异。在成年人中,IL-6和IL-18水平显著高于OSA组,在儿童中，只有IL-6和IL-23水平显著升高.
