柔红霉素在大肠癌细胞系中诱导 GLI1 依赖性凋亡。
关键词: GLI1 colorectal cancer daunorubicin hedgehog signaling p53
Mesh : Animals Humans Mice Antibiotics, Antineoplastic / pharmacology therapeutic use Apoptosis / drug effects Cell Line, Tumor Cell Proliferation / drug effects Colorectal Neoplasms / drug therapy metabolism pathology Daunorubicin / pharmacology Gene Expression Regulation, Neoplastic / drug effects HCT116 Cells Signal Transduction / drug effects Smoothened Receptor / metabolism Ubiquitination / drug effects Xenograft Model Antitumor Assays Zinc Finger Protein GLI1 / metabolism genetics
来 源:
DOI:10.3892/ijo.2024.5654
PDF(Pubmed)