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Abstract：
Long noncoding RNAs (lncRNAs) have been demonstrated to be involved in biological processes, both physiological and pathological, including cancer, cardiovascular diseases, multiple sclerosis, autoimmune hepatitis and types I and II diabetes. LncRNAs are also known to have a critical role in the physiology of skin, and in the pathology of cutaneous diseases. LncRNAs are involved in a wide range of biological activities, including transcriptional post‑transcriptional processes, epigenetics, RNA splicing, gene activation and or silencing, modifications and/or editing; therefore, lncRNAs may be useful as potential targets for disease treatment. Hidradenitis suppurativa (HS), also termed acne inversa, is a major skin disease, being an inflammatory disorder that affects ~1% of global population in a chronic manner. Its pathogenesis, however, is only partly understood, although immune dysregulation is known to have an important role. To investigate the biological relevance of lncRNAs with HS, the most differentially expressed lncRNAs and mRNAs were first compared. Furthermore, the lncRNA‑microRNA regulatory network was also defined via reverse transcription‑quantitative PCR analysis, whereby a trio of lncRNA expression signatures, lncRNA‑TINCR, lncRNA‑RBM5‑ASI1 and lncRNA‑MRPL23‑AS1, were found to be significantly overexpressed in patients with HS compared with healthy controls. In conclusion, the three lncRNAs isolated in the present study may be useful for improving the prognostic prediction of HS, as well as contributing towards an improved understanding of the underlying pathogenic mechanisms, thereby potentially providing new therapeutic targets.
摘要：
长链非编码RNA（lncRNAs）已被证明参与生物过程，生理和病理，包括癌症,心血管疾病,多发性硬化症,自身免疫性肝炎和I型和II型糖尿病。LncRNAs也被认为在皮肤的生理学中具有关键作用，以及皮肤疾病的病理学。LncRNAs涉及广泛的生物活性，包括转录后转录过程，表观遗传学,RNA剪接,基因激活和/或沉默，修改和/或编辑；因此，lncRNAs可用作疾病治疗的潜在靶标。化脓性汗腺炎（HS），也被称为痤疮，反之亦然，是一种主要的皮肤病，是一种炎症性疾病，以慢性方式影响全球约1％的人口。其发病机制,然而,只被部分理解，尽管已知免疫失调具有重要作用。为了研究lncRNAs与HS的生物学相关性，首先比较了差异表达最大的lncRNAs和mRNAs。此外，lncRNA-microRNA调控网络也通过逆转录-定量PCR分析来定义，其中有三个lncRNA表达特征，lncRNA‑TINCR,与健康对照相比，在HS患者中发现lncRNA‑RBM5‑ASI1和lncRNA‑MRPL23‑AS1显著过表达。总之,本研究中分离的三种lncRNAs可能有助于改善HS的预后预测，以及有助于增进对潜在致病机制的理解，从而潜在地提供新的治疗靶标。
