Abstract：
Transdermal drug delivery is an attractive and patient-friendly route for administering therapeutic agents. However, the skin\'s natural barrier, the stratum corneum, restricts the passage of many drugs, limiting their effectiveness. To overcome this challenge, researchers have developed various nanocarriers to enhance drug penetration through the skin. Transethosomes, a novel and promising drug delivery system, have emerged as an innovative solution for improving transdermal drug delivery. Transethosomes are a hybrid of two established nanocarriers: ethosomes and transfersomes. Ethosomes are lipid-based vesicles that can accommodate lipophilic and hydrophilic drugs, while transfersomes are deformable lipid vesicles designed to enhance skin penetration. Transethosomes combine the advantages of both systems, making them ideal candidates for efficient transdermal drug delivery. They are composed of phospholipids, ethanol, and water and exhibit high flexibility, enabling them to squeeze through the tight junctions of the stratum corneum. This abstract reviews the key characteristics of transethosomes, including their composition, preparation methods, mechanisms of action, characterization parameters, and prospects. Moreover, the recent advancements and applications of transethosomes in delivering various therapeutic agents, such as analgesics, anti-inflammatories, hormones, and skincare products, are explored. The enhanced skin penetration capabilities of transethosomes can potentially reduce systemic side effects and improve patient compliance, making them a valuable tool in the field of transdermal drug delivery. In conclusion, transethosomes represent a promising platform for overcoming the challenges of transdermal drug delivery. Their unique properties enable efficient drug permeation through the skin, offering a more controlled and effective means of administering a wide range of pharmaceutical and cosmetic products. This abstract highlights the potential of transethosomes as a valuable addition to the field of transdermal drug delivery and paves the way for further research and development in this area.
摘要：
经皮药物递送是用于施用治疗剂的有吸引力且患者友好的途径。然而,皮肤的天然屏障，角质层，限制了许多药物的通过，限制其有效性。为了克服这一挑战，研究人员开发了各种纳米载体来增强药物通过皮肤的渗透。跨细胞小体，一种新颖且有前途的药物递送系统，已成为改善透皮给药的创新解决方案。跨核小体是两种已建立的纳米载体的杂种：醇核体和传递体。醇质体是基于脂质的囊泡，可以容纳亲脂性和亲水性药物，而传递体是可变形的脂质囊泡，旨在增强皮肤渗透。经塞小体结合了两个系统的优点，使它们成为有效透皮给药的理想候选者。它们由磷脂组成，乙醇,和水，表现出很高的灵活性，使它们能够挤压角质层的紧密连接。这篇摘要回顾了跨丝体的关键特征，包括他们的组成，制备方法,行动机制,表征参数,和前景。此外，最近的进展和应用的转塞体在提供各种治疗剂，如镇痛药，抗炎药,荷尔蒙，和护肤品，正在探索。增强的跨囊体的皮肤渗透能力可以潜在地减少全身副作用并提高患者的依从性。使它们成为透皮给药领域的有价值的工具。总之,跨囊体代表了克服经皮药物递送挑战的有前途的平台。它们独特的特性使药物能够有效地通过皮肤渗透，提供了一种更加可控和有效的方法来管理各种药物和化妆品。该摘要突出了转体作为经皮药物递送领域的有价值的补充的潜力，并为该领域的进一步研究和开发铺平了道路。
