PDF(Pubmed)
Abstract：
UNASSIGNED: Both intracranial pressure (ICP) and cerebral arterial blood volume (CaBV) have a pulsatile character related to the cardiac cycle. The evolution of the shape of ICP pulses under increasing ICP or decreasing intracranial compliance is well documented. Nevertheless, the exact origin of the alterations in the ICP morphology remains unclear.
UNASSIGNED: Does ICP pulse waveform become similar to non-invasively estimated CaBV pulse during ICP plateau waves.
UNASSIGNED: A total of 15 plateau waves recorded in 15 traumatic brain injured patients were analyzed. CaBV pulse waveforms were calculated using global cerebral blood flow model from transcranial Doppler cerebral blood flow velocity (CBFV) signals. The difference index (DI) was used to quantify the similarity between ICP and CaBV waveforms. DI was calculated as the sum of absolute sample-by-sample differences between ICP and CaBV waveforms, representing the area between the pulses.
UNASSIGNED: ICP increased (19.4 mm Hg [Q1-Q3: 18.2-23.4 mm Hg] vs. 42.7 mm Hg [Q1-Q3: 36.5-45.1 mm Hg], p < 0.001) while CBFV decreased (44.2 cm/s [Q1-Q3: 34.8-69.5 cm/s] vs. 32.9 cm/s [Q1-Q3: 24.7-68.2 cm/s], p = 0.002) during plateau waves. DI was smaller during the plateau waves (20.4 [Q1-Q3: 15.74-23.0]) compared to the baselines (26.3 [Q1-Q3: 24.2-34.7], p < 0.001).
UNASSIGNED: The area between corresponding ICP and CaBV pulse waveforms decreased during the plateau waves which suggests they became similar in shape. CaBV may play a significant role in determining the shape of ICP pulses during the plateau waves and might be a driving force in formulating ICP elevation.
UNASSIGNED: Does ICP pulse waveform become similar to non-invasively estimated CaBV pulse during ICP plateau waves.
UNASSIGNED: A total of 15 plateau waves recorded in 15 traumatic brain injured patients were analyzed. CaBV pulse waveforms were calculated using global cerebral blood flow model from transcranial Doppler cerebral blood flow velocity (CBFV) signals. The difference index (DI) was used to quantify the similarity between ICP and CaBV waveforms. DI was calculated as the sum of absolute sample-by-sample differences between ICP and CaBV waveforms, representing the area between the pulses.
UNASSIGNED: ICP increased (19.4 mm Hg [Q1-Q3: 18.2-23.4 mm Hg] vs. 42.7 mm Hg [Q1-Q3: 36.5-45.1 mm Hg], p < 0.001) while CBFV decreased (44.2 cm/s [Q1-Q3: 34.8-69.5 cm/s] vs. 32.9 cm/s [Q1-Q3: 24.7-68.2 cm/s], p = 0.002) during plateau waves. DI was smaller during the plateau waves (20.4 [Q1-Q3: 15.74-23.0]) compared to the baselines (26.3 [Q1-Q3: 24.2-34.7], p < 0.001).
UNASSIGNED: The area between corresponding ICP and CaBV pulse waveforms decreased during the plateau waves which suggests they became similar in shape. CaBV may play a significant role in determining the shape of ICP pulses during the plateau waves and might be a driving force in formulating ICP elevation.
摘要：
■颅内压（ICP）和脑动脉血量（CaBV）均具有与心动周期相关的脉动特性。在ICP增加或颅内顺应性降低的情况下，ICP脉冲形状的演变已得到充分证明。然而，ICP形态改变的确切原因尚不清楚.
■在ICP平台波期间，ICP脉冲波形是否变得类似于非侵入性估计的CaBV脉冲。
■分析了15例脑外伤患者中记录的15个高原波。使用经颅多普勒脑血流速度（CBFV）信号的整体脑血流模型计算CaBV脉冲波形。差异指数(DI)用于量化ICP和CaBV波形之间的相似性。DI计算为ICP和CaBV波形之间的绝对逐样本差异之和，表示脉冲之间的区域。
■ICP增加（19.4mmHg[Q1-Q3：18.2-23.4mmHg]与42.7mmHg[Q1-Q3：36.5-45.1mmHg]，p<0.001），而CBFV下降（44.2cm/s[Q1-Q3：34.8-69.5cm/s]32.9厘米/秒[Q1-Q3：24.7-68.2厘米/秒]，p=0.002）在高原波浪中。与基线（26.3[Q1-Q3：24.2-34.7]相比，在高原波期间DI较小（20.4[Q1-Q3：15.74-23.0]），p<0.001)。
■在高原波期间，相应的ICP和CaBV脉冲波形之间的面积减小，这表明它们的形状相似。CaBV可能在确定平台波期间ICP脉冲的形状中起重要作用，并且可能是制定ICP升高的驱动力。
■在ICP平台波期间，ICP脉冲波形是否变得类似于非侵入性估计的CaBV脉冲。
■分析了15例脑外伤患者中记录的15个高原波。使用经颅多普勒脑血流速度（CBFV）信号的整体脑血流模型计算CaBV脉冲波形。差异指数(DI)用于量化ICP和CaBV波形之间的相似性。DI计算为ICP和CaBV波形之间的绝对逐样本差异之和，表示脉冲之间的区域。
■ICP增加（19.4mmHg[Q1-Q3：18.2-23.4mmHg]与42.7mmHg[Q1-Q3：36.5-45.1mmHg]，p<0.001），而CBFV下降（44.2cm/s[Q1-Q3：34.8-69.5cm/s]32.9厘米/秒[Q1-Q3：24.7-68.2厘米/秒]，p=0.002）在高原波浪中。与基线（26.3[Q1-Q3：24.2-34.7]相比，在高原波期间DI较小（20.4[Q1-Q3：15.74-23.0]），p<0.001)。
■在高原波期间，相应的ICP和CaBV脉冲波形之间的面积减小，这表明它们的形状相似。CaBV可能在确定平台波期间ICP脉冲的形状中起重要作用，并且可能是制定ICP升高的驱动力。
