PDF(Pubmed)
Abstract：
Angiogenin (ANG) is a specialised secreted ribonuclease, also known as RNase5, that is widely expressed in vertebrates. ANG dysregulation is closely associated with the development of breast, nasopharyngeal, and lung cancers. In recent years, studies have found that ANG not only induces neovascularisation by activating endothelial cells, but also plays a regulatory role in the plasticity of cancer cells. Cellular plasticity plays pivotal roles in cancer initiation, progression, migration, therapeutic resistance, and relapse. Therefore, it is a promising biomarker for cancer diagnosis, prognostic evaluation, and therapy. This review summarises the current knowledge regarding the roles and clinical applications of ANG in cancer development and progression.
摘要：
血管生成素（ANG）是一种特殊的分泌型核糖核酸酶，也称为RNase5，在脊椎动物中广泛表达。ANG失调与乳房发育密切相关,鼻咽,和肺癌。近年来,研究发现，ANG不仅通过激活内皮细胞诱导新生血管形成，而且在癌细胞的可塑性中也起着调节作用。细胞可塑性在癌症发生中起关键作用，programming,迁移,治疗抗性,和复发。因此,它是癌症诊断的一种有前途的生物标志物，预后评估，和治疗。这篇综述总结了关于ANG在癌症发生发展中的作用和临床应用的最新知识。
