PDF(Pubmed)
Abstract：
UNASSIGNED: Abnormal cerebrospinal fluid (CSF)/serum albumin ratio (Qalb) levels have been observed in patients with cognitive impairment. Few studies have specifically focused on Lewy Body Disease (LBD), and the results were controversial. Thus, we conducted this systematic review and meta-analysis to investigate Qalb levels in patients with LBD by including data from different studies.
UNASSIGNED: We systematically searched PubMed, Embase, Cochrane Library, and Web of Science databases for a collection of studies containing studies comparing Qalb levels in patients with LBD and healthy controls (including healthy controls and other dementia subtypes). In the initial search, 86 relevant papers were retrieved. Standardized mean differences (SMD) in Qalb levels were calculated using a random effects model.
UNASSIGNED: A total of 13 eligible studies were included. Mean Qalb levels were significantly higher in patients with LBD compared to healthy older adults [standardized mean difference (SMD): 2.95, 95% confidence interval (CI): 0.89-5.00, Z = 2.81, p = 0.005]; and were significantly higher in patients with LBD than in patients with Alzheimer\'s disease (AD) (SMD: 1.13, 95% CI: 0.42-1.83, Z = 3.15, p = 0.002);whereas mean Qalb levels were significantly higher in patients with frontotemporal lobar degeneration (FTLD) compared to those with AD (SMD: 1.13, 95% CI,0.14-2.13, Z = 2.24, p = 0.03).
UNASSIGNED: Qalb levels were significantly elevated in LBD patients compared with normal older adults and were higher than those in AD patients and FTLD patients, which helped in the differential diagnosis of LBD from other neurodegenerative diseases.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42024496616.
UNASSIGNED: We systematically searched PubMed, Embase, Cochrane Library, and Web of Science databases for a collection of studies containing studies comparing Qalb levels in patients with LBD and healthy controls (including healthy controls and other dementia subtypes). In the initial search, 86 relevant papers were retrieved. Standardized mean differences (SMD) in Qalb levels were calculated using a random effects model.
UNASSIGNED: A total of 13 eligible studies were included. Mean Qalb levels were significantly higher in patients with LBD compared to healthy older adults [standardized mean difference (SMD): 2.95, 95% confidence interval (CI): 0.89-5.00, Z = 2.81, p = 0.005]; and were significantly higher in patients with LBD than in patients with Alzheimer\'s disease (AD) (SMD: 1.13, 95% CI: 0.42-1.83, Z = 3.15, p = 0.002);whereas mean Qalb levels were significantly higher in patients with frontotemporal lobar degeneration (FTLD) compared to those with AD (SMD: 1.13, 95% CI,0.14-2.13, Z = 2.24, p = 0.03).
UNASSIGNED: Qalb levels were significantly elevated in LBD patients compared with normal older adults and were higher than those in AD patients and FTLD patients, which helped in the differential diagnosis of LBD from other neurodegenerative diseases.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42024496616.
摘要：
■在认知障碍患者中观察到脑脊液（CSF）/血清白蛋白比率（Qalb）水平异常。很少有研究专门针对路易体病（LBD），结果是有争议的。因此，我们进行了系统评价和荟萃分析,通过纳入不同研究的数据,调查LBD患者的Qalb水平.
■我们系统地搜索了PubMed，Embase,科克伦图书馆,和WebofScience数据库收集了一系列研究，其中包含比较LBD患者和健康对照（包括健康对照和其他痴呆亚型）中Qalb水平的研究。在最初的搜索中,检索到相关论文86篇。使用随机效应模型计算Qalb水平的标准化平均差(SMD)。
■共纳入13项符合条件的研究。与健康的老年人相比，LBD患者的平均Qalb水平显着升高[标准化平均差异（SMD）：2.95，95％置信区间（CI）：0.89-5.00，Z=2.81，p=0.005]；LBD患者的平均Qalb水平显着高于阿尔茨海默氏病（AD）患者（SMD：1.13，95％CI：0.42-1.83，Z=3.15，P=2FTemCI13
■与正常老年人相比，LBD患者的Qalb水平显着升高，并且高于AD患者和FTLD患者，这有助于LBD与其他神经退行性疾病的鉴别诊断。
■https://www.crd.约克。AC.英国/普华永道/，标识符CRD42024496616。
■我们系统地搜索了PubMed，Embase,科克伦图书馆,和WebofScience数据库收集了一系列研究，其中包含比较LBD患者和健康对照（包括健康对照和其他痴呆亚型）中Qalb水平的研究。在最初的搜索中,检索到相关论文86篇。使用随机效应模型计算Qalb水平的标准化平均差(SMD)。
■共纳入13项符合条件的研究。与健康的老年人相比，LBD患者的平均Qalb水平显着升高[标准化平均差异（SMD）：2.95，95％置信区间（CI）：0.89-5.00，Z=2.81，p=0.005]；LBD患者的平均Qalb水平显着高于阿尔茨海默氏病（AD）患者（SMD：1.13，95％CI：0.42-1.83，Z=3.15，P=2FTemCI13
■与正常老年人相比，LBD患者的Qalb水平显着升高，并且高于AD患者和FTLD患者，这有助于LBD与其他神经退行性疾病的鉴别诊断。
■https://www.crd.约克。AC.英国/普华永道/，标识符CRD42024496616。
