PDF(Pubmed)
Abstract：
Jingmen tick virus (JMTV) is a newly identified segmented flavivirus that has been recognized in multiple hosts, such as humans, buffalos, bats, rodents, mosquitos and ticks. Various clinical cases and studies manifested that JMTV is a true arbovirus with wide host spectrum and showed potential threats toward public health. JMTV has been reported in multiple countries in Asia, Europe, Africa, and America. Moreover, wild boars serve as an important intermediary between humans and the wild ecological system. In China, it has been reported in nine provinces, while the prevalence and the distribution of JMTV in most regions including Jiangxi Province are still unknown. Thus, to profile the distribution of JMTV in Jiangxi Province, an epidemiological investigation was carried out from 2020 to 2022. In current study, 66 ticks were collected from 17 wild boars in Jiangxi Province. The results showed that 12 out of 66 ticks were JMTV positive, indicating JMTV is prevalent in ticks and boars in Jiangxi Province. The genome sequences of JMTV strain WY01 were sequenced to profile viral evolution of JMTV in China. Phylogenetic analysis divided JMTV strains into two genotypes, Group I and Group II. WY01 belongs to Group II and it shares the closest evolutionary relationship with the Japan strains rather than the strains from neighboring provinces in China suggesting that JMTV might have complex transmission routes. Overall, current study, for the first time, reported that JMTV is prevalent in Jiangxi Province and provided additional information concerning JMTV distribution and evolution in China.
摘要：
荆门蜱病毒（JMTV）是一种新发现的分段黄病毒，已在多个宿主中得到认可，比如人类，水牛,蝙蝠,啮齿动物,蚊子和蜱。各种临床病例和研究表明，JMTV是一种真正的虫媒病毒，具有广泛的宿主谱，并显示出对公共卫生的潜在威胁。JMTV在亚洲多个国家都有报道，欧洲,非洲,和美国。此外，野猪是人类与野生生态系统之间的重要中介。在中国,据报道，九个省，而JMTV在包括江西省在内的大多数地区的流行和分布仍未知。因此，为了描述JMTV在江西省的分布，从2020年到2022年进行了流行病学调查.在目前的研究中,从江西省17头野猪中采集了66只蜱。结果显示，66只蜱中有12只是JMTV阳性，说明JMTV在江西省蜱和公猪中普遍存在。对JMTV菌株WY01的基因组序列进行测序，以描述中国JMTV的病毒进化。系统发育分析将JMTV菌株分为两种基因型，第一组和第二组。WY01属于第二组，它与日本菌株而不是来自中国邻近省份的菌株具有最紧密的进化关系，这表明JMTV可能具有复杂的传播途径。总的来说,目前的研究，第一次,据报道，JMTV在江西省很普遍，并提供了有关JMTV在中国的分布和演变的其他信息。
