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Abstract：
Choriocarcinoma syndrome is a rare form of tumor lysis syndrome that predominantly occurs in patients with metastatic germ cell tumors, particularly those presenting with extensive lung metastases. We report a case of a previously healthy 37-year-old male who presented with a painless left-sided neck lump and nipples with an increased sensitivity to light touch. Workup revealed a significantly elevated beta-human chorionic gonadotropin, a testicular mass, and innumerable pulmonary metastases, suggesting metastatic non-seminomatous germ cell tumor. Following the initiation of chemotherapy with etoposide, ifosfamide, and cisplatin (VIP), the patient experienced a rapid decline in respiratory function, culminating in acute respiratory distress syndrome and subsequent death from respiratory failure six weeks after starting treatment. This case emphasizes the importance of early detection and intervention in managing non-seminomatous germ cell tumors and highlights the critical need for awareness of choriocarcinoma syndrome\'s risks, the challenges of treatment delays for fertility preservation, and the exploration of alternative therapeutic strategies to improve outcomes in this high-risk patient population.
摘要：
绒毛膜癌综合征是一种罕见的肿瘤溶解综合征，主要发生在转移性生殖细胞肿瘤患者中。特别是那些出现广泛肺转移的患者。我们报告了一例先前健康的37岁男性，其表现为无痛的左侧颈部肿块和乳头，对轻触的敏感性增加。检查显示β-人绒毛膜促性腺激素显著升高，睾丸肿块,和无数的肺转移，提示转移性非精原细胞生殖细胞肿瘤。依托泊苷化疗开始后，异环磷酰胺,和顺铂（VIP），患者呼吸功能迅速下降，在开始治疗后六周，最终导致急性呼吸窘迫综合征和随后的呼吸衰竭死亡。该病例强调了早期发现和干预在管理非精原细胞生殖细胞肿瘤中的重要性，并强调了对绒毛膜癌综合征风险意识的迫切需要。生育保护的治疗延迟的挑战，并探索替代治疗策略以改善该高危患者人群的预后。
