Abstract：
OBJECTIVE: To compare fetal pulmonary artery Doppler parameters between pregnant women with asthma and healthy pregnant women.
METHODS: This prospective, cross-sectional study was conducted on 50 pregnant women diagnosed with asthma and 61 healthy pregnant women. Fetal pulmonary artery Doppler parameters and the fetal main pulmonary artery acceleration time/ejection time (PATET) ratio were compared between the study and control groups. Thereafter, the study group was divided into two subgroups as non-severe and severe asthma. PATET ratio was compared between the subgroups.
RESULTS: The fetal main pulmonary artery acceleration time was 25 ms in pregnant women with asthma and 33 ms in the healthy group, indicating a statistically significant difference (p=0.001). The acceleration time/ejection time ratio was statistically lower in the asthma group (0.185 vs. 0.240, p<0.001). The acceleration time/ejection time ratio was 0.172 in patients with severe asthma and 0.195 ms in the non-severe study group (p=0.156). In the maternal asthma group, the PATET ratio of those who went to the NICU due to respiratory distress was also 0.188, and the PATET ratio of those who went to the NICU for other reasons was 0.269 (p=0.053).
CONCLUSIONS: Fetal pulmonary artery acceleration time and PATET decreased statistically in pregnant women with severe or non-severe asthma. Maternal asthma is associated with changes in pulmonary Doppler parameters in the fetus.
METHODS: This prospective, cross-sectional study was conducted on 50 pregnant women diagnosed with asthma and 61 healthy pregnant women. Fetal pulmonary artery Doppler parameters and the fetal main pulmonary artery acceleration time/ejection time (PATET) ratio were compared between the study and control groups. Thereafter, the study group was divided into two subgroups as non-severe and severe asthma. PATET ratio was compared between the subgroups.
RESULTS: The fetal main pulmonary artery acceleration time was 25 ms in pregnant women with asthma and 33 ms in the healthy group, indicating a statistically significant difference (p=0.001). The acceleration time/ejection time ratio was statistically lower in the asthma group (0.185 vs. 0.240, p<0.001). The acceleration time/ejection time ratio was 0.172 in patients with severe asthma and 0.195 ms in the non-severe study group (p=0.156). In the maternal asthma group, the PATET ratio of those who went to the NICU due to respiratory distress was also 0.188, and the PATET ratio of those who went to the NICU for other reasons was 0.269 (p=0.053).
CONCLUSIONS: Fetal pulmonary artery acceleration time and PATET decreased statistically in pregnant women with severe or non-severe asthma. Maternal asthma is associated with changes in pulmonary Doppler parameters in the fetus.
摘要：
目的：比较哮喘孕妇和健康孕妇的胎儿肺动脉多普勒参数。
方法：这种前瞻性，我们对50名诊断为哮喘的孕妇和61名健康孕妇进行了横断面研究.比较两组胎儿肺动脉多普勒参数及胎儿主肺动脉加速时间/射血时间(PATET)比值。此后,研究组分为非重度哮喘和重度哮喘两个亚组.比较亚组之间的PATET比率。
结果：哮喘孕妇胎儿主肺动脉加速时间为25ms，健康组为33ms，表明统计学上的显著差异(p=0.001)。哮喘组的加速时间/喷射时间比在统计学上较低（0.185vs.0.240，p<0.001)。重度哮喘患者的加速时间/射血时间比为0.172，非重度哮喘患者为0.195ms（p=0.156）。在母亲哮喘组中，因呼吸窘迫进入NICU的患者的PATET比率也为0.188,因其他原因进入NICU的患者的PATET比率为0.269(p=0.053).
结论：重度和非重度哮喘孕妇胎儿肺动脉加速时间和PATET均有统计学降低。母体哮喘与胎儿肺多普勒参数的变化有关。
方法：这种前瞻性，我们对50名诊断为哮喘的孕妇和61名健康孕妇进行了横断面研究.比较两组胎儿肺动脉多普勒参数及胎儿主肺动脉加速时间/射血时间(PATET)比值。此后,研究组分为非重度哮喘和重度哮喘两个亚组.比较亚组之间的PATET比率。
结果：哮喘孕妇胎儿主肺动脉加速时间为25ms，健康组为33ms，表明统计学上的显著差异(p=0.001)。哮喘组的加速时间/喷射时间比在统计学上较低（0.185vs.0.240，p<0.001)。重度哮喘患者的加速时间/射血时间比为0.172，非重度哮喘患者为0.195ms（p=0.156）。在母亲哮喘组中，因呼吸窘迫进入NICU的患者的PATET比率也为0.188,因其他原因进入NICU的患者的PATET比率为0.269(p=0.053).
结论：重度和非重度哮喘孕妇胎儿肺动脉加速时间和PATET均有统计学降低。母体哮喘与胎儿肺多普勒参数的变化有关。
