Abstract：
In this study, we compared the effectiveness of various methods used in the treatment of cattle with cutaneous papillomatosis. Ivermectin, Tarantula cubensis extract, levamisole, autovaccine, and a combination of T. cubensis extract + levamisole were administered to the animals. The animals were divided into six equal groups. Animals in the control group (n = 10) did not receive any treatment. The animals in the experimental group were administered Ivermectin [three times a week, n = 10, subcutaneous, (SC)], Tarantula cubensis extract (twice a week, n = 10, SC), autologous vaccine (three times at 10-day intervals, n = 10, SC), levamisole [twice at one-week intervals, n = 10, intramuscular (IM)], and levamisole + Tarantula cubensis extract (concurrently). All animals used in the study were monitored for three months at an interval of 15 days. No regression was detected in the papillomas of the control group animals, but recovery was recorded in animals treated with ivermectin at a rate of 70% (7/10), while it was 60% (6/10) in those treated with T. cubensis extract, 100% (10/10) in those treated with autovaccine, 50% (5/10) in those treated with levamisole, and 90% (9/10) in those treated with the combination of T. cubensis extract + levamisole. Significant differences were found between the control group and all treatment groups. Recovery mostly occurred within 45-60 days (P < 0.05). The five treatment modalities applied for the treatment of bovine cutaneous papillomatosis were statistically evaluated and all methods of treatment were effective at different rates. The most precise and effective treatment method was the autovaccine one.
摘要：
在这项研究中,我们比较了各种方法治疗牛皮肤乳头状瘤病的效果。伊维菌素,cubensis,左旋咪唑,自体疫苗，并向动物施用T.cubensis提取物+左旋咪唑的组合。将动物分成六个相等的组。对照组(n=10)中的动物不接受任何治疗。实验组动物给予伊维菌素[每周三次,n=10，皮下，(SC)],cubensis狼尾草提取物（每周两次，n=10，SC），自体疫苗（每10天间隔三次，n=10，SC），左旋咪唑[每隔一周两次，n=10，肌内（IM）]，和左旋咪唑+塔兰图拉提取物（同时）。以15天的间隔监测研究中使用的所有动物三个月。对照组动物的乳头状瘤未检测到消退，但用伊维菌素治疗的动物以70%(7/10)的比率恢复，而在用枯草提取物处理的人群中，它是60%(6/10)，100％（10/10）在接受自体疫苗治疗的患者中，左旋咪唑治疗的患者中有50％（5/10），和90％（9/10）在那些用枯萎病菌提取物+左旋咪唑的组合处理。在对照组和所有治疗组之间发现显著差异。恢复大多发生在45-60天(P<0.05)。对用于治疗牛皮肤乳头状瘤病的五种治疗方式进行了统计学评估，所有治疗方法均以不同的有效率。最精确和有效的治疗方法是自体疫苗。
