Abstract：
Continuous treatment with drugs is a crucial requirement for managing various clinical conditions, including chronic pain and neuropsychiatric disorders such as depression or schizophrenia. Associative learning processes, i.e. Pavlovian conditioning, can play an important role for the effects of drugs and could open new avenues for optimizing patient treatment. In this narrative literature review, we summarize available data in experimental animals regarding the behaviorally conditioned effects of psychostimulants such as d-amphetamine and cocaine, the dopamine receptor agonist apomorphine, the dopamine receptor antagonist haloperidol, morphine and antidepressant drugs. In each section, the drug under discussion is briefly introduced, followed by a detailed examination of conditioning features, including doses and dosing regimens, characteristics of the conditioning process such as test environments or specific conditioned stimuli, testing and conditioned response characteristics, possible extinction or reconditioning or reversal training, neural mechanisms, and finally, the potential clinical relevance of the research area related to the drug. We focus on key outcomes, delve into methodical issues, identify gaps in current knowledge, and suggest future research directions.
摘要：
持续的药物治疗是管理各种临床状况的关键要求，包括慢性疼痛和神经精神疾病，如抑郁症或精神分裂症。联想学习过程，即巴甫洛夫调节，可以对药物的作用发挥重要作用，并可以为优化患者治疗开辟新的途径。在这篇叙事文献综述中，我们总结了实验动物中有关d-苯丙胺和可卡因等精神兴奋剂的行为条件作用的可用数据，多巴胺受体激动剂阿扑吗啡，多巴胺受体拮抗剂氟哌啶醇，吗啡和抗抑郁药.在每个部分，简要介绍了正在讨论的药物，然后详细检查调理功能，包括剂量和给药方案，条件过程的特征，如测试环境或特定条件刺激，测试和条件响应特性，可能的灭绝或修复或逆转训练，神经机制，最后，与该药物相关的研究领域的潜在临床相关性。我们专注于关键成果，深入研究有条理的问题，确定当前知识中的差距，并提出了未来的研究方向。
