Abstract：
The utility of neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) as prognostic markers in Feline Leukemia Virus (FeLV) and Feline Immunodeficiency Virus (FIV) infections has not yet been investigated. The aim of this study was to investigate these leukocyte ratios in retrovirus-positive cats and to evaluate their prognostic value for survival. This retrospective case-control study included 142 cats, 75 FIV-Antibodies (Ab)-positive, 52 FeLV-Antigen (Ag)-positive, and 15 FIV-Ab+FeLV-Ag-positive, and a control population of 142 retrovirus-negative age-, sex-, and lifestyle-matched cats. Signalment, complete blood count at the time of serological testing, and outcome were recorded. Leukocyte ratios were compared within the same case-control population, among the three retrovirus-seropositive populations, and were related to survival time. No significant difference was found in NLR, MLR, or PLR between FIV-Ab-positive and FIV-Ab+FeLV-Ag-positive cats and their cross-matched controls. In the FeLV-Ag-positive population, MLR was significantly lower than in the control population (0.05 and 0.14, respectively, P=0.0008). No ratio discriminated among the three infectious states. No ratio was significantly different between survivors and non-survivors in the population of FIV-Ab-positive cats. MLR at diagnosis was significantly higher in FeLV-Ag-positive cats that died 1-3 years after diagnosis than in FeLV-Ag-positive cats still alive at 3 years (P=0.0284). None of the three ratios could predict retroviruses-positive cats that would survive to the end of the study. Overall the results indicate that NLR, MLR, and PLR are not significantly different among retrovirus statuses evaluated and had a very limited prognostic value for the survival time in retrovirus-positive cats.
摘要：
中性粒细胞-淋巴细胞比率(NLR)的效用，单核细胞-淋巴细胞比率（MLR），和血小板-淋巴细胞比率（PLR）作为猫白血病病毒（FeLV）和猫免疫缺陷病毒（FIV）感染的预后标志物尚未进行研究。这项研究的目的是研究逆转录病毒阳性猫中的这些白细胞比率，并评估其对生存的预后价值。这项回顾性病例对照研究包括142只猫，75FIV抗体（Ab）阳性，52FeLV-抗原（Ag）阳性，和15FIV-Ab+FeLV-Ag-阳性，和142个逆转录病毒阴性年龄的对照人群-，sex-,和生活方式相匹配的猫。信号，血清学检测时的全血细胞计数，并记录结果。在相同的病例对照人群中比较白细胞比率，在三个逆转录病毒血清阳性人群中，与生存时间有关。NLR没有发现显著差异，MLR,FIV-Ab阳性和FIV-Ab+FeLV-Ag阳性猫及其交叉匹配对照之间的PLR。在FeLV-Ag阳性人群中，MLR显著低于对照组(分别为0.05和0.14，P=0.0008)。在三种感染状态中没有区别的比率。在FIV-Ab阳性猫群体中,幸存者和非幸存者之间的比率没有显著差异。诊断时的MLR在诊断后1-3年死亡的FeLV-Ag阳性猫明显高于3年仍存活的FeLV-Ag阳性猫(P=0.0284)。这三个比率都不能预测逆转录病毒阳性的猫会存活到研究结束。总体而言，结果表明，NLR，MLR,和PLR在评估的逆转录病毒状态之间没有显着差异，并且对逆转录病毒阳性猫的存活时间具有非常有限的预后价值。
