ARID1A 抑制 R - loop 介导的 STING - I 型干扰素途径激活抗肿瘤免疫。
关键词: ARID1A R-loops STING SWI/SNF complex anti-tumor immunity cancer immunotherapy cytosolic DNA type I IFN
Mesh : Animals Humans Mice CD8-Positive T-Lymphocytes / immunology metabolism Cell Line, Tumor DNA-Binding Proteins / metabolism Exodeoxyribonucleases / metabolism Immune Checkpoint Inhibitors / pharmacology therapeutic use Interferon Type I / metabolism Membrane Proteins / metabolism genetics Mice, Inbred C57BL Mutation Neoplasms / immunology genetics Nuclear Proteins / metabolism Phosphoproteins / metabolism Signal Transduction Transcription Factors / metabolism Male Chemokines / genetics metabolism
来 源:
DOI:10.1016/j.cell.2024.04.025
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