Abstract:
Arsenic has been an element of great interest among scientists for many years as it is a widespread metalloid in our ecosystem. Arsenic is mostly recognized with negative connotations due to its toxicity. Surely, most of us know that a long time ago, arsenic trioxide was used in medicine to treat, mainly, skin diseases. However, not everyone knows about its very wide and promising use in the treatment of cancer. Initially, in the seventies, it was used to treat leukemia, but new technological possibilities and the development of nanotechnology have made it possible to use arsenic trioxide for the treatment of solid tumours. The most toxic arsenic compound - arsenic trioxide - as the basis of anticancer drugs in which they function as a component of nanoparticles is used in the fight against various types of cancer. This review aims to present the current solutions in various cancer treatment using arsenic compounds with different binding motifs and methods of preparation to create targeted nanoparticles, nanodiamonds, nanohybrids, nanodrugs, or nanovehicles.
摘要:
多年来,砷一直是科学家们非常感兴趣的元素,因为它是我们生态系统中广泛存在的类金属。砷由于其毒性而被认为具有负面含义。当然,我们大多数人都知道很久以前,三氧化二砷在医学上用于治疗,主要是,皮肤病。然而,不是每个人都知道它在癌症治疗中非常广泛和有前途的用途。最初,在七十年代,它被用来治疗白血病,但是新的技术可能性和纳米技术的发展使得使用三氧化二砷治疗实体瘤成为可能。最有毒的砷化合物-三氧化二砷-作为抗癌药物的基础,它们作为纳米颗粒的组成部分,用于对抗各种类型的癌症。这篇综述旨在介绍使用具有不同结合基序的砷化合物以及制备靶向纳米颗粒的各种癌症治疗的当前解决方案。纳米金刚石,纳米杂种,纳米药物,或纳米车辆。