PDF(Pubmed)
Abstract：
Various injectants are available for the treatment of carpal tunnel syndrome. This systematic review and network meta-analysis was conducted to investigate the effectiveness of different injection therapies in alleviating the symptoms of carpal tunnel syndrome. Various databases were searched for relevant studies from inception until May 10, 2023. Eligible studies were identified using the patient (P), intervention (I), comparison (C), and outcomes (O) model, which involved (P) participants with carpal tunnel syndrome, (I) an intervention based on injection therapy, (C) the use of placebo or another injectant as a control treatment, and (O) the measurement of clinical and electrodiagnostic outcomes of interest. A total of 18 studies were included in the analysis. The network meta-analysis revealed that platelet-rich plasma is effective in the treatment of carpal tunnel syndrome in terms of symptom and pain relief and functional improvement in both the short and long term, whereas steroids are effective only in the short term. Additionally, injections of dextrose solution may offer long-term pain relief as well as short- and long-term symptom alleviation and functional improvement. The study findings suggest that platelet-rich plasma should be used as the first-line treatment for carpal tunnel syndrome, with dextrose and steroids serving as alternative treatment options.
摘要：
各种注射剂可用于治疗腕管综合征。进行了系统评价和网络荟萃分析，以研究不同注射疗法缓解腕管综合征症状的有效性。从开始到2023年5月10日，都在各种数据库中搜索相关研究。使用患者（P）确定合格的研究，干预（I），比较（C），和结果(O)模型，涉及（P）腕管综合征的参与者，(I)基于注射疗法的干预措施，(C)使用安慰剂或另一种注射剂作为对照治疗，和(O)感兴趣的临床和电诊断结果的测量。共有18项研究纳入分析。网络荟萃分析显示，富血小板血浆在短期和长期症状和疼痛缓解以及功能改善方面均可有效治疗腕管综合征，而类固醇仅在短期内有效。此外,注射葡萄糖溶液可以提供长期疼痛缓解以及短期和长期症状缓解和功能改善。研究结果表明，富血小板血浆应作为腕管综合征的一线治疗方法，葡萄糖和类固醇作为替代治疗选择。
